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Sedative-Hypnotic-Anxiolytic Drugs (BZs (Alprazolam (anxiety, panic,…

- - - - Potentiate GABA
      - ↑ the frequency of Cl channel opening
      - Have no GABA mimetic activity
      - Act through BZ receptors and they are part of the GABAa complex
      - BZ1 mediates sedation and BZ2 mediates antianxiety and impairment of cognitive function
    - - Prolong GABA activity
      - ↑ duration of Cl channel opening
      - Have GABA mimetic activity at high dose
      - Have their own binding sites on the GABAa complex
      - Also inhibit complex I of electron transport chain