Cholesterol - Transport MAP
1st step in lipids
Absorption
and
formation of the chylomicron
Summary
- key in fat digestion is
OPTIMIZE SURFACE AREA
2ns step in lipids
CHYL MIC BOMB
enter Lymphatics
gets ApoC2 and ApoE
--> from HDL passing by
ApoC2
--> CUTS and CLEAVES lipids
--> using LPL lipase
ApoE
--> final EXIT for rEEEmnants
EXIT of Chylo at the liver as rEEEMnant pieces
Summary
CHYLO MIC BOMB
B 48 BOMBER
--> drops CHYLO MIC BOMBS on the lymphatic system
HDL donate ApoE and also ApoC1
--> to the CHYLO MIC BOMB
--> note the CHYLOs originally only have APO B48 to enter the lymphatics
--> they require the HDLs to give them the other lipo proteins
*HDL
HDL maturation
ApoA1
- A1 activates LCAT
--> causes HDL cholesterol esterification
--> HDL needs LCAT to be able to carry and store cholesterol
HDL donate ApoE and also ApoC2
CHYLO MIC BOMB
- CHYLOs start ONLY with = APO B48
--> allow them to enter the lymphatics - CHYLOs require the HDLs to give them ApoC1 and ApoE
VLDLs = preproLDL
- VLDL start ONLY with = APO B100
--> B100 useless at this point, only work for LDLs at their receptor - VLDL require the HDLs to give them ApoC1 and ApoE
- VLDL = APO B100 + ApoC2 + ApoE
IDL= proLDL
- IDL come ffrom VLDLs
--> after VLDL unloads all of its FFAs
--> then VLDL loses its ApoC2 CUT and CLEAVER
--> becomes IDL - IDL = APO B100 + ApoE
CHYLO MIC BOMB
HDL donate ApoE and also ApoC2
- CHYLOs start ONLY with = APO B48
--> allow them to enter the lymphatics - CHYLOs require the HDLs to give them ApoC1 and ApoE
VLDLs = preproLDL
HDL donate ApoE and also ApoC2
VLDLs = preproLDL
- VLDL start ONLY with = APO B100
--> B100 useless at this point, only work for LDLs at their receptor - VLDL require the HDLs to give them ApoC1 and ApoE
- VLDL = APO B100 + ApoC2 + ApoE
IDL= proLDL
- IDL come ffrom VLDLs
--> after VLDL unloads all of its FFAs
--> then VLDL loses its ApoC2 CUT and CLEAVER
--> becomes IDL - IDL = APO B100 + ApoE
2ns step in lipids
chylomicron enter Lymphatics
Summary
ApoB100
B100 needed for entry for LDL at LDL receptors
ApoB100 on at STARTING transporter = VLDL
--> all the way through the VLDL - VIL - CHAIN is
--> to its final product = LDL
entire goal of ApoB100 is to gain entry of final transport protein = LDL
*HDL
HDL maturation
ApoA1
- A1 activates LCAT
--> causes HDL cholesterol esterification
--> HDL needs LCAT to be able to carry and store cholesterol
HDL donate ApoE and also ApoC2
CHYLO MIC BOMB
- CHYLOs start ONLY with = APO B48
--> allow them to enter the lymphatics - CHYLOs require the HDLs to give them ApoC1 and ApoE
VLDLs = preproLDL
- VLDL start ONLY with = APO B100
--> B100 useless at this point, only work for LDLs at their receptor - VLDL require the HDLs to give them ApoC1 and ApoE
- VLDL = APO B100 + ApoC2 + ApoE
IDL= proLDL
- IDL come ffrom VLDLs
--> after VLDL unloads all of its FFAs
--> then VLDL loses its ApoC2 CUT and CLEAVER
--> becomes IDL - IDL = APO B100 + ApoE
CHYLO MIC BOMB
HDL donate ApoE and also ApoC2
- CHYLOs start ONLY with = APO B48
--> allow them to enter the lymphatics - CHYLOs require the HDLs to give them ApoC1 and ApoE
VLDLs = preproLDL
HDL donate ApoE and also ApoC2
VLDLs = preproLDL
- VLDL start ONLY with = APO B100
--> B100 useless at this point, only work for LDLs at their receptor - VLDL require the HDLs to give them ApoC1 and ApoE
- VLDL = APO B100 + ApoC2 + ApoE
IDL= proLDL
- IDL come ffrom VLDLs
--> after VLDL unloads all of its FFAs
--> then VLDL loses its ApoC2 CUT and CLEAVER
--> becomes IDL - IDL = APO B100 + ApoE
