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TM: Typhoid (i) (Pathogenesis (organ involvement (BM (biopsy + aspirate…

- - - - bleeding
      - perforation
      - septicaemia
      - shock
      - death
- - - - typhoid fever
      - gram -ve
      - human only
      - most severe illness
      - 3 antigens
        
        O: somatic heat-stable long chain polysacc
        
        H: flagella, strongly immunogenic, induces Ab formation rapidly + in high titres following infection/immunisation
        
        Vi antigen
    - - gram -ve
      - paratyphoid fever
      - usually milder, less serious, lower mortality
      - similar symptoms