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TM: Cholera (Intro (over 200 serogroups (V cholerae O1 + O139 cause…
TM: Cholera
Intro
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3 million cases yrly - 100,000 deaths
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can be endemic, epidemic or pandemic
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survives in water
Broad street pump in London responsible for huge outbreak, John Snow (epidemiologist) tracked all cases back to this pump
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Pathogenesis
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absorptive capacity of colon is overwhelmed by large vol of fluid from upper intestine (can't resorb enough)
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esp in malnutrition, overcrowding, disasters
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Dx
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metabolic acidosis (due to loss of bicarb, high lactate)
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