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Parents have child with Sickle Cell Anemia this was discovered after…

- - - - monosaccharides disaccharides and polysaccharides
    - - triglycerides phospholipids steroids cholesterol eoisancoids
    - - Proteins go with amino acid for DNA
        
        amino acids monomers of proteins
        
        long chain of amino acids polypeptide
        
        made of nitrogens bases with sugar
      - nucleotides
      - central dogma
        
        DNA goes to RNA in transcriptions
        
        RNA goes to ribosomes with proteins in translation
        
        tRNA takes amino acid to ribosomes
  - - - Nucleous synthesis ribosomes
        
        has chromatin condense chromosomes
        
        chromosomes held by centromeres
        
        makes one sister chromatid
        
        uncondense and refills during division
        
        inside the nucleus
      - studded on the Rough ER which helps transport proteins
        
        Smooth ER helps synthesis and transport Lipids
        
        Golgi body edits, modifies and transports the proteins
      - tRNA adds amino acid to ribosomes
    - - Perioxomes detox free radicals
    - - has cell junctions receptors and proteins on surface
  - - - primary structure sequence of amino acids
        
        secondary structure has alpha & beta helix and pleated sheets
        
        tertiary is 3d shape of proteins globular or functional
        
        quaternary structure 2 or more bonds still has 3D shape
- - - - hinders oxygen carrying ability
        
        defective hemoglobin
  - - - defects in a gene
        
        must have both genes from mom and dad
        
        if only have 1 gene then a carrier
- - - - they form into the shape of a sickle or crescent
        
        cells stick together can't move through vessels
        
        interfere with blood flow possible tissue death
- - - - vessels part of cardiovascular system help transport
        
        blood goes to heart to be pumped
        
        cardiovascular system helps distribution of nutrients in body
        
        nutrients are carried via blood from digestive system
        
        through the body and do the heart eventually
        
        RBC need oxygen and nutrients to function
        
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        can be treated with blood transfusions
        
        bone marrow transplants and medications too
  - - - flexible fit through vessels not get stuck
        
        RBC live 120 days sickle live 10-20
        
        sickle destroy by spleen
        
        spleen lymphatic system filters blood for infections
        
        liver also filters out sickle cells but not fast enough
        
        causes jaundice yellow of skin
        
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