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T Cell (Function (CD4+ T cell (:warning: Help B cell produce antibodies, …
T Cell
Function
CD4+ T cell
:warning: Help B cell produce antibodies
:warning: Help activate CD8+ T cell
:warning: Produce cytokines
:warning: Activate APC
T reg
:warning: Immune regulation
:warning: Help suppress effector T cell
CD8+ T cell
:warning: Recognised and kill infected cell
Memory T cell
:warning: Ability to stimulate adaptive immune response to protect against future disease
:warning: Respond to recall antigen
Activation
Intracellular
:fountain_pen: Infected cell
:fountain_pen: Antigen protein synthesis by cell
:fountain_pen: Peptide bind to MHC Class I on ER
:fountain_pen: MHC Class I present peptide to surface
:fountain_pen: CD8+ T cell bind to antigen peptide
Extracellular
Macrophage
:!!: Macrophage engulf bacterium produce peptide
:!!: Peptide bind to MHC Class II in vesicles
:!!: Peptides transported by MHC Class II to cell surface
:!!: Helper T cell recognize peptide antigen with MHC Class II and activates macrophage
B Cell
:!!: B cell bind bacteria and engulf producing peptides
:!!:Bound peptides transported by MHC class II to the cell surface
:!!: Helper T cell recognize peptide antigen with MHC Class II and activates B cell
Signal for activation
:recycle: Antigen
Mediated by TCR and MHC
:recycle: Co-Stimulators
Surface molecules expressed by APCs
:recycle: Cytokines
Produce by APC and T cell
Response
CD8+ T cell
:check: Cytotoxic T cell kill infected cell
CD4+ T cell
Antigen-Presenting Cell
:check: CD4+ T cell secrete cytokines ( Eg: IL-2) to attract netrophils and monocytes to tissue
:check: Th1 activate macrophage to induce cell mediated immune response
:check: IL-2 bind to receptor IL-2 on T cell to induce cell proliferation
B cell
:check: Naive B cell encounter antigen
:check: Become APC
:check: Th2 activae B cell to produce antibodies
:check: B cell present antigen to CD4+