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Nephrotic Syndrome Causes (Minimal Change Disease (Findings (LM: no…
Nephrotic Syndrome Causes
Minimal Change Disease
Associations
Most common cause in children
Can be associated with tumors (e.g. multiple mieloma)
Findings
LM: no changes
EM:
effacement of the foot processes
Selective glomerular proteinuria
Tx
Responds well to corticosteroids
Good prognosis
Focal Segmental Glomerulosclerosis
Most common cause in black populations
Findings
LM: segmental sclerosis
IM: IgM and C3 inside the sclerotic regions
EM: effacement of the foot processes
Tx
ESRD if untreated
Immunossupressive tx
Membranous nephropathy