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DNA REPAIR (BASE EXCISION REPAIR (AP LYSE (3), DNA POLYMERASE (ADDS), AP…
DNA REPAIR
BASE EXCISION REPAIR
AP LYSE
3
DNA POLYMERASE
ADDS
AP ENDONUCLEASE
5
DNA LIGASE
OKAZAKI
DNA GLYCOSYLASE
REMOVAL
ALL PHASES
MISMATCH
INCERSIONS, DELETIONS, MISMATCHES
S / G2 PHASE
MICROSATELITE
COMAPRING TO A PREVIOUS STRAND
MISMATCH
REMOVE AND RESEAL
DNA SLIPPAGE
LYNCH
NUCLEOTIDE EXCISION
ENDONUCLEASE
POLYMERASE, LIGASE
XERODERMA PIGMENTOSUM
THYMIDINE
G1 PHASE
DOUBLE STRAND DAMAGE
NON HOMO END JOININ
FANCONI ANEMIA
cant repair DNA
AML
90% BM FX
VUNARABLE TO DNA STRAND CROSS LINKS
ATAXIA TELE
11
CANCERS, LYMPHOMAS