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Effects of intermittent Fasting on Glucose and lipid Metabolism (Two…
Effects of intermittent Fasting on Glucose and lipid Metabolism
Two Variants of intermittent fasting
Time-Ristricted Feeding (TRF)
Eating at certain times
Balancing Circadian systems with fasting
Intermittent Energy Restriction (IER)
Restricts energy intake every other day
Fasting ranges from 20 to 36 hr
Conclusion on both human and rodent study on the two variant intermittent fasting
Rodent Study
IER Fast
Reduced glucose levels
Improved hepatic insulin sensitivity.
maintained lipid homeostasis when fighting off high-fat content
TRF Fast
Reduced adiposity and liver steatosis (build-up)
Reduced Cholesterol
Improved glucose
Human Study
IER Fast
Alternate Fasting
9% weight loss
Reduction in LDL-cholesterol and TAG reduction
Improved Lipids
Struggle to sustain energy during the fast
Modified Fasting
Decline in insulin
Difficult to compare the effect with a placebo
vascular function became an issue
TRF Fast
Increased LDL and HDL cholesterol
Decreased TAG
Goals of Intermittent Fasting
Weight-Loss Management
Improving Metabolism
Purpose
The effects of IER and TRF on glucose and lipid metabolism.
Which method was most effective on humans and rodents?
Methods of Intermittent Fasting
Rodents
IER Fast
Alternating Fasting days during study
Worked in intervals of 4 weeks to 1 year
TRF Fast
Feeding the rodents at night (dark/active phase) and not eat for twelve hours.
Humans
IER Fast
Alternate day total fasting
26 obese male and female were used
Combination of healthy and overweight participants
Modified Fasting
Measured blood markers of cardiometabolic risk
Took a placebo approach
TRF Fast
Humans are to eat once a day in the evening
must not eat until 10-11 hrs later