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Infant previously diagnosed with circulatory problems and anemia. Examined…
Infant previously diagnosed with circulatory problems and anemia. Examined and diagnosed with sickle cell disease.
Indirect upstream causes
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If the mother only had sickle cell trait and the father didn't then the child will most likely be a carrier but not have the disease
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Background
Cells
Structures
Cell has 3 Main Parts
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Nucleus
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within the nucleus are nucleoli, where ribosomal sub-units are assembled
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Organelles
Golgi apparatus
packages, modifies, separates proteins for secretion from the cell
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Smooth ER
Site of lipid and steroid synthesis, lipid metabolism and drug detox
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microfilaments
form cells cytoskeleton, involved in muscle contraction
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Amino Acids
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proteins shape
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Hydrogen bonds
beta-pleated sheet, alpha helix
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Direct cause
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Red blood cells that contain normal hemoglobin are disc-shaped so they can move easily through large and small blood vessels to deliver oxygen
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Sickle-shaped cells are not flexible and can stick to vessel walls, causing a clot or blockage that slows or stops the flow of blood
Sickle Cell
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Complications
lack of oxygen in tissue can cause attacks of sudden severe pain, called pain crises
sickle cells cannot change shape easily, they tend to burst apart
Normal red blood cells live about 90 to 120 days, but sickle cells last only 10 to 20 days
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Causes injury to blood vessels in eye usually in the retina were blood vessels can over grow and bleed....vision impairment or loss
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Sickling in blood vessels of the lungs can deprive a person’s lungs of oxygen, causes tissue to be damaged and ruined
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Increases risk for pregnant mother of miscarriage, premature,low weight babies
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Treatment
A blood and bone marrow transplant is currently the only cure for some patients who have sickle cell
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