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Nephrotic Syndrome (Clinical Manifestations (Anasarca, Proteinuria,…
Nephrotic Syndrome
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Associated Diet
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Lean cuts of meat, less red meat more chicken and fish
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Prevention
Limiting intake of dietary sodium, often from salt.
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Pathophysiology
- When the glomerular basement membrane is damaged,
- There is an increase in permeability that initially allows proteins of small molecular weight to leak out,
- Through the Bowman's capsule and proximal tubule.
- As the condition worsens, larger proteins ( albumin) also leak out and are excreted in urine.
- As the body continues to lose protein, serum albumin is decreased resulting in a decrease in osmotic pressure.
- Generalized oedema occurs due to low osmotic pressure.
- Sodium and water retention occurs, causing more oedema.
- The disease progresses to renal failure due to persistent hypovolaemia and accelerated atherosclerosis as a result of hyperlipidaemia.
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