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pioglitazone Thiazolidinediones (side effects (Blurred vision, Cold…
pioglitazone
Thiazolidinediones
effects on the kidneys
Monitor for S&S hypoglycemia (possible when insulin/sulfonylureas are coadministered).
Monitor closely for S&S of CHF or exacerbation of symptoms with preexisting CHF.
Lab tests: Baseline serum ALT, then q2mo for first y, then periodically (more often if elevated); periodic HbA1c, Hgb and Hct, and lipid profile.
Discontinue drug if ALT >3 times ULN or patient has jaundice.
Monitor weight and notify physician of development of edema.
Indication
It works by helping to restore your body's proper response to insulin.
it is used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes.
Route
It is taken orally 15-30 minutes before a meal.
It should be taken 2,3 or 4 times a day.
side effects
Blurred vision
Cold temperature
Muscle weakness
Irritability
Tremors
Confusion
Tingling in the finger
Storage
Tablets should be stored at room temperature, below 25 C.
definition
It an antidiabetic drug in the class of medications known as meglitinides. It trade name Actos. under the group Thiazolidinediones
mechanism of action
Decrease insulin resistance and thereby increase glucose uptake by muscle adipose tissue.
And decrease glucose production by the liver.
Contraindications
Anemia
A certain eye problem (macular edema)
Liver disease
Bladder cancer
Heart disease