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Path: Liver 1 - Structure, Function, Dysfunction (i) (Liver disease…
Path: Liver 1 - Structure, Function, Dysfunction (i)
Liver disease
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less common than heart disease, cancer, stroke
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importance of hx, exam (least helpful with liver) + tests
Causes of liver damage
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NAFLD: a/w metabolic syndome (type 2 insulin resistant DM, obesity, etc)
viruses (acute +/- chronic in some) Hep A,B,C,D,E
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Structure
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stable cell pop
capable of regeneration, but usually don't unless damaged
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dual blood supply
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venous drainage: portal tracts (triads of smallest branches of hep artery, bile duct + portal vein) -> sinusoids -> central venules -> hep vein -> IVC -> right ventricle
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under microscopy: light parts = sinusoids, dark parts = parenchyma
Bile drainage
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small ductules form from canaliculi, which join to for small ducts in portal tracts
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in 75%, pancreatic duct joins CBD @ ampulla of vater (entrance to SI)
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Liver function
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intermediary metabolism
alteration +/or storage of vits, mins, glycogen (+ abnormally copper, iron, fat)
immune
detect, capture + clear bacteria, viruses, macromolecules
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haematopoiesis in foetal infant, before BM takes over