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Path: Liver 1 - Structure, Function, Dysfunction (ii) (Liver damage…

- - - - v rare - 1 in a million
      - occlusion of hep veins
      - presents with triad of abdo pain, ascites, liver enlargement
- - - - if v extensive risk of ALF
      - recovery if transient + no ALF
- - - - diffuse distortion of liver architecture
      - fibrous bands/septa around multiple regenerative nodules variable size (size has no significance) - these nodules look different from mets as these are global whereas mets have normal parenchyma between them
      - distorted vasc relationships
        
        obliteration/thrombosis of veins within liver
        
        collat channels/shunts form
        
        sinusoids become "capillarised" (lose fenestrations)
        
        Hep venous pressure gradient (HVPG) rises
        
        portal HTN
        
        functional capacity reduced/diminished - risk of decompensation
      - risk of HCC
- - - - infection, bleeding, hypotension, alcohol, medications, dehydration, trauma, surgery