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ADAPTIVE (T CELL (SUPER ANTIGENS (S AUREUS (TSST - 1 TOXIN), S PYOGENES…

- - - - SIGNALLING INTO THE [CELL]
    - - HYPERVARIABLE DOMAIN
  - - - VIRUS INFECTED CELLS
      - ALL NUCLEATED CELLS
      - BINDS
        
        TCR
        
        CD 8
      - ONE HEAVY PLUS SMALL B CHAIN
    - - PERFORINS
      - GRANZYME
      - FAS LIGAND
        
        [CD 95
        
        CASPASES
        
        PROGRAMED CELL DEATH
  - - - MHC 2
        
        ALFA BETA
        
        BINDS WITH ACIDIFIED LYSOZOME
        
        CHAIN REALESED
        
        SURFACE
        
        CAN BE SEEN FOR T
        
        BETA 2 GLYCOPROTEIN
        
        AB
        
        ANTI PHOSPHOLIPID SYNDROME
      - APC -B7
        
        CD 28 - T CELL
      - ACTIVATION
        
        APC
        
        DENDRITIC
        
        MO
        
        B CELLS
        
        IL-2
      - FUNCTION
        
        CD 8 ACTI
        
        MO ACTIV
        
        B CELL ACTIV
    - - FUNCTION
        
        MO ACTIVATE
        
        CD8 ACTIV
        
        IG G
        
        STIMULATION
      - CYTOKINES
        
        IFN GAMMA
        
        ACTIVATE MO
        
        MACROPHAGE
        
        IL 12
        
        ACTIVATE
        
        1 more item...
        
        IL 12 DEFICIENCY
        
        2 more items...
        
        TNF ALFA
        
        TH 1 ACTIV
        
        IFN DEFIC.
        
        SEVERE TBC SINCE CHILDHOOD
        
        STEM CELL TRANSPL.
        
        IL 2
        
        T CELL GROWTH
        
        ACTIVATES
        
        B
        
        NK
        
        ALDESLEUKIN
        
        RCC
      - TBC
        
        LISTERIA
    - - FUNCTION
        
        B CELL ACTIV
        
        IG E
        
        IG A
      - CYTOKINES
        
        IL4
        
        ACTIV TH2
        
        SUPRESS TH1
        
        IGE PROMO
        
        IL 5
        
        EOS ACTIV
        
        IGA PROD
        
        GI BACT
        
        ALLERGIES!!!
        
        IL 10
        
        ANTI INFLAM
        
        INHIBITS TH 1
  - - - TSST - 1 TOXIN
    - - EXOTOXIN A OR C
    - - SHOCK
- - - - STRUCTURE
        
        LIGHT
        
        VDJ
        
        MILIONS OF RECOMBINATIONS
        
        CHROM 14
        
        IN BONE MARROW
        
        HEAVY
    - - STRUCTURE
        
        HEAVY
      - FUNCTION
        
        CH 2
        
        COMPLEMENT
        
        CH3
        
        MACROPHAGE
        
        PROTEIN A
        
        S. AUREUS
  - - - ALWAYS 2 SIGNALS NEEDED
        
        PATHOGEN
        
        AG
        
        CROSSLINKS
        
        B CELL
        
        PRESENTS IT TO THE T CELL
        
        2 more items...
        
        PRESENTS IT TO T CELL
        
        2 more items...
      - THE STRONGEST
    - - LPS
        
        MANY AG BIND
        
        INDUCES
        
        IGM ATTACK
      - WEAKER
      - POLYSACH. CAPSULE
    - - T CELL DEPENDANT
        
        STRONGER
        
        PROTEIN AG ONLY
        
        CLASS SWITCHING IG G,E, A
        
        MEMORY
      - INDEPANDANT
        
        WEAKER
        
        NON -PROTEIN
        
        IG M
        
        NO MEMORY
      - CONJUGATED VAX
        
        B CELL
        
        SHOW IT TO T CELL
        
        STRONG PROTECTION
        
        POLYSACH
        
        NO T CELL STIM
        
        WEAKER PROT
        
        TYPES
        
        H.INFLUENZA
        
        N.MENINGITIDIS
        
        S.PNEUMONIEA
  - - - EBV
      - COMPLEMENT
    - - MOST NOT PLSMA
    - - ALL B CELLS
  - - - FUNCTIONS
        
        OPSONIZATION
        
        NEUTRALIZATION
        
        COMPLEMENT ACTIV.
      - PROTEIN A
        
        S. AUREUS
        
        FC
        
        IG G
        
        BLOCKS COMPONENT ACTIV
      - CLASS SWITCH
        
        IG M
        
        IL 4
        
        T CELL
        
        IL 5
      - TYPES
        
        IG M
        
        10 BINDING SITES
        
        ACTIVATOR OF CLASSICAL PATHWAY
        
        CANT CROSS PLACENTA
        
        IG G
        
        OPSONIN
        
        CROSSES PLACENTA
        
        IG A
        
        MUCOSAL
        
        BIND BY PIgR
        
        POLYMERIC IG RECEPTOR
        
        TRANSCYTOSIS
        
        GI
        
        MILK BABY
        
        IG E
        
        ALLERGY
        
        ADDC
  - - - STEM CELL - PRE B CELL - IMMATURE B CELL
        
        LYMPH NODE
        
        GERMINAL FOLLICULE
        
        AFFINITY
        
        MATURE
        
        IGM
        
        1 more item...
- - - - GRANULOMATOUS DIZ
  - - - ACTIVATE
        
        T CELL
        
        T H 1
        
        SECRETE
        
        IFN GAMMA
        
        ACTIVATE
        
        1 more item...
- - - - TCR, CD3 -
  - - - TCR, CD 3
        
        WEAK
        
        DEATH
  - - - SELF ANTIGENS
        
        STRONG
        
        DEATH