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Neurology - Dopaminergic Pathways (*Dopaminergic Pathways 4 pathways…

- - - - Notes:
        
        note that most Doapmine producing neurons are in the midbrain = meso, rest are in the hypothal = tubero
        
        midbrain = meso DA neurons
        --> VTA and substantia nigra
        
        hypothal DA neurons = tubero
        -->
    - - *Tuberinfundibular Dopaminergic Pathway
        
        nucleus accumbans (hypothalamus) --> anterior pituitary gland
        
        dopamine inhibitory pathway from the hypothalamus on prolactin release from the anterior pit
        
        Antipsycotics --> prolactinemia
        
        since you are stopping the 1/4 dopamine pathways that is meant for inhibiting prolactin release
        --> hypothal control over the anterior PIT
        
        Clinical Cases
        
        Clinical Case
        
        3 more items...
      - *Mesolimbic Dopaminergic Pathway
        
        VTA = ventral tegmental area (medial midbrain) --> nucleus accumbens (minor to amygdala)
      - *Nigrostriatal Dopaminergic Pathway
        
        substantia nigra (midbrain) --> striatum (= caudate + putamen)
        
        *Direct and Indirect pathway of PD
        -
      - *Mesocortical Dopaminergic Pathway
        
        VTA = ventral tegmental area (medial midbrain) --> frontal cortex
    - - Tuberoinfundibular --> Prolactin DA Pathway
        
        Infundibulum (= pituitary stalk of hypothalamus) --> anterior pituitary gland (causes release of prolactin)
      - MesoCortical DA Pathway
        
        VTA = Ventral Tegmental Area (midbrain) --> Frontal cortex (mainly the prefrontal cortex)
      - MesoLimbic DA Pathway
        
        VTA = Ventral Tegmental Area (midbrain) --> Nucleus Accumbens (also to other limbic structures)
        --> remember "V-TA DA-NA" song makes DANA very positive, happy and hallucinate
      - Nigro-Striatum DA Pathway
        
        substantia nigra (midbrain) --> striatum (caudate + Putamen)
        --> remember striatum as mix of a STRAIGHT CAUTIOUS DATER + PutaMEN
        --> Striatum = Caudate + Putamen