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Pharmacology - Cancer Chemotherapy (*Chemotoxicity (*DIPF ABC +…
Pharmacology - Cancer Chemotherapy
*Cyclophosphamide
basically mustard gas
excreted by the kidneys
metabolized to acrolin by the kidneys
--> this is toxic to the kidneys
--> meslin = 5mercaptoethanesulfate is given with cyclophosphamide to stop the acrolin from damaging the kidneys
Clinical Cases
Clinical Case
Clinical Case
Notes
:
note that
*RNA interferance chemotherapy
siRNA = small interfering RNA
miRNA = micro RNA
*CDK inhibitors
CDK 4/6 inhibitors
recall the 4 cycles of the cell
--> G1 phase
--> S phase
--> G2 phase
--> M phase
*Thymidilate Inhibitors = Folate DHF THF pathway
methotrexate
5 Flurouracil
note that leucovorin = THF derivative that doesn't require DHF reductase
--> thus it bypasses DHF reductase step
--> thus it reduces the effects of methotrexate
leucovorin actually increases the toxicity of 5-FU though in cancer cells since it forces 5-FU to bind thymidilate stronger and stop pyrimidine synthesis
*SERMs
SERMs = selective estrogen receptor modulators
Tamoxafen, Raloxifene
*Ritz-tuximab
3 main diseases + 1
*Bavacizumab
-
*Chemotoxicity
*DIPF
ABC + Methotrexate
