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Anti parasite (Drug used in amebiasis (Metronidazole (MOA: reduce…
Anti parasite
Drug used in amebiasis
Concept: life cycle :star:
Metronidazole
MOA: reduce Ferredoxin/nitroreductase
Free radical :checkered_flag:
Tinidazole
Paromomycin
MOA: cell membrane leakage
Iodoqunol
Emetine and dehydroemetine
MOA: inhibit movement of mRNA
Chloroquine
Diloxanide furoate
Other protozoa
Nitazoxanide
MOA: inhibit PFOR enzyme
Pentamidine
MOA: bindding kinetoplast
Suramin
MOA: inhibit energy synthesis
Melarsoprol
MOA: inhibit pyruvate kinase
Nifurtimox
MOA: reduce and crete free radical
Sodium stibogluconate and meglumine antimonite
Miltefosine
Anthemintic drug
inhibit microtubule
MOA: inhibit beta-tubulin
Inhibit polymerization :checkered_flag:
Benzimidazole
GABA(A) agonist
MOA: activate GLUCI
Muscle paralysis :checkered_flag:
ยานี้ไม่ผ่าน BBB ทำให้ไม่มีผลต่อ GABA(A) receptor ในสมอง และ affinity น้อยกว่า
Ivermectin
Ca2+ influx enhancers
MOA: influx Ca2+ pass in cell membrance
Spastic paralysis
Praziquantel
NMJ depolarization
MOA: block NMJ (depolarization)
Pyrantel pamoate
Oxantel
Other group
Diethylcarbamazine
Niclosamide
Anti-malarial drug
Group
Quinolines
Chloroquine
MOA: inhibit heme polymerase
Inhibit heme polymerization :checkered_flag:
ห้ามใช้กับ G6PD dif. เพราะยาเป็น oxidant
Quinine
ผลข้างเคียง: Cinchonism
Mefloquine
Anti-folate drug
Sulfadoxine-pyrimethamine
electron transport inhibitor
Primaquine
MOA: react ubiquinone and free radical
inhibit electron transport :checkered_flag:
Atovaquone
Artemisnin
MOA: endoperoxide react with Fe/Heme
Artemisnin radical :checkered_flag:
Other
Protein synthesis inhibitor
Doxycycline
Tetracycline
Clindamycin
Concept
life cycle :star:
Hypnozoite: ระยะที่ฝังตัวในตับ
P.ovale
and
P.vivax
Drug resistance
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