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Immunology - HLA and MHC1 Pathways (*HLA = Human Leukocyte Antigens …

- - - - MHC Class 1
        
        on surface of all human cells
        
        recognized by cytotoxic T cells (CD8)
        
        MHC 1 = "call Toll free 1-800, but beta micro charge after"
        --> MHC1 = TCRs and CD 8 / beta2-microglobulin
      - *MHC 2 = Major Histocompatability Complex 2
        
        MHC 2 = "show 24 is INVARIANT"
        --> MHC2 = TCRs and CD 4 / 4 for helping / invariant chain
        
        Clinical Cases
        
        Clinical Case
        
        Notes:
        
        note that
        
        Clinical Case
        
        MHC Class 2
        
        on surface of ONLY APCs
        
        recognized by Helper T cells (CD4)
        
        Clinical Case
        
        Notes:
        
        MHC 1 vs 2
        --> the MHC2 class, since it presents exogenous foreign antigens, it endocytoses them into endosomes
        --> these endosome are first fused with lysosomes
        --> become endolysosomes
        
        endolysosomes are acidic (only for MHC 2 and exogenous foreign)
        --> the acidification of endolysosomes is needed for MHC 2 since it's invariant (plunger) is removed by the acidicfication
        --> that blocks the antigen binding spot until the MHC 2 transport vesicle fuses with the endolysosome
        
        HLA MHC 2 Case #2
        
        Notes:
        
        note that the invariant chain of the MHC 2 class AP protein is degraded in endolysosomes
        
        the invariant chain is a blocker at the end of the MHC 2 during its transport to the endolysosome
        --> to make sure no antigens or proteins attach to its binding site
        
        once in the endolysosome, acidification causes the invariant chain to break down in order to make room for ingested foreign antigens to bind to the MHC 2 to be presented to CD4 = helper T cells
        
        think that MHC 2 want to stay INVARIANT before they reach the forein antigens
        
        Clinical Case