Placental insufficiency
Acute placental separation
Hypoxia, asphyxiation, ischaemia
Umbilical torsion/compression
Chest compression
Signs of prematurity at birth
Reduced surfactant production
Atelectasis
Neuronal cell damage due to lipid peroxidation, calcium influx into cells and neurotoxins such as nitric oxide and glutamate.
Neuronal cell death
Reperfusion injury from oxygen free radicals
Excessive
Insufficient
Rapid expulsion of fetus
Reduced time under pressure in birth canal
Lack of stimulus to inhibit secretion of sedative neurosteroids
Sedative effect on foal
Increased fetal and placental secretions of adenosine, pregnanolone and allopregnanolone
Hypoxic ischaemic encephalopathy
Perinatal asphyxia syndrome
Neonatal maladjustment syndrome
Abnormal behaviour, obtunded mentation
Increased recumbency
Hypersensitivity to stimuli
Anaerobic respiration and lactate synthesis
Increased exposure to pathogens
Metabolic acidosis
Increased risk of injury
Failure to suckle
SEPSIS
Increased risk of ischaemic ulceration of GIT
Impaired mucosal barrier
Increased risk of infection from enteric absorption
Increased risk of laryngeal cysts and DDSP
Abnormal breathing patterns and generalised weakness
Increased risk of aspiration pneumonia
Vasodilation
Hypotension
Reduced peripheral perfusion
Compensatory tachypnoea
Failure of passive transfer
Immunologically naive. Reduced ability to combat infection