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Acute Liver Failure is loss of liver function that occcurs rapidly in days…
Acute Liver Failure is loss of liver function that occcurs rapidly in days or weeks usually in a person who has no pre-existing liver disease.
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Pathophysiology
Hyperbilirubinemia is almost always present at presentation. The degree of hyperbilirubinemia is one indicator of the severity of liver failure. Peripheral vascular resistance and BP decrease, causing hyperdynamic circulation with increased heart rate and cardiac output. Portosystemic encephalopathy occurs, possibly secondary to increased ammonia production by nitrogenous substances in the gut. Immune system defects develop; they include defective opsonization, deficient complement, and dysfunctional WBCs and killer cells.
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