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Fructose Metabolism (Steps (Fructose Phosphorylation (is catalyzed by…

- - - - hexokinase
      - Fructokinase
    - - Fructose 1-P
  - - - Aldolase A
        
        is found in
        
        most tissues
      - Aldolase B
        
        is found in
        
        liver
        
        kidney
        
        small intestines
      - Aldolase C
        
        is found in
        
        brain
    - - Glyceraldehyde 3-Phosphate
      - DHAP
- - - - polyruia
      - polyphagia
      - dehydration
    - - deficiency of fructokinase
    - - increased levels of fructose in blood
  - - - Increased AMP/ATP ratio
        
        hyperuricemia
        
        lactic acidemia
      - decreased gluconeogenesis
        
        hypoglycemia
        
        vomiting
    - - accumulation of Fructose 1-Phosphate in tissues
    - - deficiency of Aldolase A/B/C