Please enable JavaScript.
Coggle requires JavaScript to display documents.
Alzheimer Disease (Risk Factors (Down's Syndrome, TBI, APOE 4 genotype…
Alzheimer Disease
Risk Factors
Down's Syndrome
TBI
APOE 4 genotype
HTN
family history
vascular factors
advanced age
Treatment
partial N-methyl-D-aspartate antagonist
antidepressants
cholinesterase inhibitors
anxiolytics
symptom management
neuroleptics
Epidemiology
quickly becoming a leading cause of death
female risk slightly higher than male
200,000 Americans <60 affected
African Americans more prevalent than whites or hispanics
6.08 million Americans >60 affected
Diagnosis
MMSE
lumbar puncture
clinical symptomology
brain imaging
Pathophysiology
Tau Theory
microtubules disintegrate
neuron transport collapse
becomes tangled
NFT disrupt neuron communication
Tau pairs together
cell death
Amyloid Theory
plaques combine with other fragments
plaques block transmission of neuronal messages
formation of beta -amyloid plaques
Clinical Presentation
Mild
confusion
compromised judgement
memory loss
Moderate
difficulty recognizing people
difficulty with language
shortened attention span
inability to organize thoughts
Severe
incontinence
seizures
weight loss
increasing sleeping
Lakhan, S. E. (2019). Alzheimer disease.
Medscape.
Retrieved from
https://emedicine.medscape.com/article/1134817