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Regulation of Glycolysis (Allosteric regulation (AMP (if levels are high…
Regulation of Glycolysis
Covalent Activation of glycogenolysis
Ligand binds GPCR
Stimulates production of cAMP
PKA is activated
Phosphorylase kinase is activated
Glycogen phosphorylase is activated
Covalent Inhibition of glycogenesis
Ligand binds GPCR
Stimulates production of cAMP
PKA is activated
Glycogen synthase is phosphorylated and deactivated
Allosteric regulation
AMP
if levels are high
muscle glycogen phosphorylase is activated
Calcium
if it is released by msucle
binds to calmodulin
activates phosphorylase kinase b
glycogen phosphorylase is activated
Glucose 6 P
if levels are high
activates Glycogen synthase
inhibits Glycogen phosphorylase