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PDHC Pathologies (caused by (Cofactor deficiencies (Thiamine deficiency…

- - - - causes
        
        Wernicke Korsakoff Syndrome/Encephalopathy
      - Mechanism
        
        Lack of thiamine inhibits function of E1 subunit of PDHC
  - - - causes
        
        Neurological Disturbances and death
      - Mechanism
        
        Arsenic binds SH groups of reduced lipoic acid, preventing function of E2 subunit of PDHC
  - - - causes
        
        Congenital lactic acidosis
      - Mechanism
        
        lack of alpha subunit of E1 causes decreased availability of PDHC