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ETC and ATP Synthase Inhibitors (Uncouplers (Oligomycin (Antibiotic,…
ETC and ATP Synthase Inhibitors
Uncouplers
Oligomycin
Antibiotic
inhibits ATP synthesis by blocking F0 proton channel
UCPs
Channel membrane protein
Disrupts H+ gradient by creating pores in inner mitochondrial membrane
leads to
disruption of ATP production and release of heat
Synthetics
2,4 dinitrophenol
weight loss, antiseptic, pesticide
Disrupts H+ gradient by shuttling protons across inner mitochondrial membrane
Inhibitors
Rotenone
Pesticide
inhibits transfer of electrons from Complex I to ubiquinone
leads to
creation of reactive oxygen species and mitocondrial damage
Antimycin A
Pesticide
inhibits transfer of electrons from Ubiquinone to Complex III
leads to
no production of ATP
H2S, CN-, CO, NaN3
chemicals
inhibit transfer of electrons from Complex IV to O2