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Pharmacology - HIV antivirals (dropped image link (*HARRT therapy for HIV…
Pharmacology - HIV antivirals
*HARRT therapy for HIV patients
HARRT = highly active antiretroviral therapy
2 NNRT NUN NERD BOWTIE drugs
--> note these are good since they act allosterically on the reversee transcriptase
--> vs. the NRTIs that bind competitively to RT
1 Integrase GRABBER GRAVIR drug
HAART HIV lives TOO FAST and when he is DIAGNOSED with HIV he goes to his 2 FAVOURITE drug dealers under the 3 TREE = NERD TIE MOM and DAD
HAART = 2 MAIN drug dealers = NERD TIE MOM AND DAD
--> 2 NERD TIEs
the 2 NERD TIES tell him he must TURN AWAY from his life of HAART HARD HIV DRUGS and PICK ONLY ONE PATH forward to a better life
HAART 1 PATH to better = become a NUN NERD TIE
--> NNRTIs
HAART 2 PATH to better = CHAIN UP his INTEGRA GRAVY CAR
--> INTEGRA GRAVY
HAART 3 PATH to better = CHAIN UP his NAVY GEAR PROPELLOR ACE speed boat
*NNRTIs NUN NERD BOWTIE drugs
reverse transcriptase inhibitors
*NNRTIs
-
NERD TIES couple defeat the BAID AID and his REVERSE TRAIN when he tried to REVERSE TRAIN over their daughter
NERD TIE mom and dad = NRTIs
--> requires a PHOSPHORYLATION KEY
NERD TIES defeat the BAND AID REVERSE TRAIN TRANSCRIPTASE
the BAND AID REVERSE TRAIN tries to REVERSE onMRS NERD TIE when she was PREGNANT and alone so MRS NERD TIE PROTECTED her baby to be by sicking her ZDV ZOMBIE BIRD with PURPLE AXES on the REVERSE TRAIN to stop him
MRS NERD TIE ZDV ZOMBIE BIRD PURPLE AXES against BAND AID on BABY
MR NERD TIE does his part to stop the REVERSE TRAIN from REVERSING on his family by PUTTING up a CHAIN STOP on the DNA TRACK so it cant REVERSE ANYMORE, to do this he REQUIRES A PHOSPHORYLATION KEY to jam it into the circuit board
MR NERD TIE = REVERSE TRAIN TERMINATION of DNA TRACK
MR NERD TIE = REQUIRES PHOSPHORYLATION KEY
--> vs the NUN NERD TIE
NERD TIEs when they aren't fighting REVERSE TRAINS witht heir POSPHORYLATION KEY TERMINATION TRACK STOPPERS are making a FRANKENSTEIN BANDAID with body parts from GOOD DEALSZ from VOODOO COSTANZA in NEW YORK
NERD TIES = BAND AID FRANKENSTEIN
NERD TIE = DEALSZ VOODOO COSTANZA
VOODOO COSTANZA DEALSZ are from
VOODOO CONSANZA DEALSZ = ZOMBIE ZDV bird
--> ZDV for pregnancy is safe
VOODOO CONSANZA DEALSZ = LAMB VOODOO with STAFF VODOO
--> LAMB VOODOO = lamivudine
--> STAFF VODOO = stavudine
VOODOO CONSANZA DEALSZ = DDI EYES
--> DDI
VOODOO CONSANZA DEALSZ = ABC CADAVER
--> Abacavir
the final touch on the other NUCLEOTIDE / NUCLEOSIDE side of the BAND AID FRANKENSTEIN bed is the TIN of EARS for the final touch of the BAND AID FRANKENSTEIN
--> TIN OF EARS = tinofovir
*NNRTIs
-
NNRTI NUN NERD BOW TIE hears the CONFFESION of the BAND AID
NNRTI NUN NERD BOW TIE = NNRTI drugs
confession BAND AID HIV
the BAND AID tells the NUN NERD BOW TIE that he CRASHED into church when he REVERSED TRANCRIPTED his TRAIN into the church and knocked over the DONATION basket that said you are NOT REQUIRED TO DONATE INTRACELLULAR METAL BALLS for entry into the church
NUN NERD BOW TIE BAND AID conffession = RVERSE TRAIN TRANSCRIPTASE
NUN NERD BOW TIE BAND AID conffession = DO NOT DONATE INTRACELLULAR METAL BALLS
--> vs the NRTIs where they do require it
then BAID AID confesses also that while he was in the church he found a BUM sleeping on a PEW so to teach him a lesson he started rubbing his leg and gave him a LEG RASH and then he PEED on the BUMS LIVER and gave him HEPATOTOXICITY
NUN NERD BOW TIE BAND AID conffession = BUM asleep gets RASH
NUN NERD BOW TIE BAND AID conffession = BUM asleep gets LIVER PEED on ---> HEPATOTOXICITY
the reason why the BUM on the PEW was sleeping was because he was dreaming about the time he confessed to sleeping with a NUN who got thrown out of the church for being pregnant because NUN NERD BOW TIE is not allowed to get PREGNANT
NUN NERD BOW TIE BAND AID conffession = BUM has wild dreams about NUNs
NUN NERD BOW TIE BAND AID conffession = NUN NERD BOW TIE not allowed to get PREGNANT
--> reason why she gets kicked out of the church
NNRT NUN NERD BOW TIE the mission to save the ELF ALVANCHE ELVES
NNRTIs
ELF ALVANCHE ELVES = efavirenz
the NNRTI NUN with NERD BOWTIE sends in the NAVY NEVIRAPINE
NNRTI NAVY = NEVIRAPINE
then RAPPLING MARINES RILPIVIRINE come to DELIVAROO DELAVIRDINE
--> RAPPLING MARINES RAPILVIRINE
--> DELIVEROO = DELAVIRIDINE
next the ELFS IN AVALANCHE EFAVIRINE are found by the NNRTI NUN with NERD BOW TIE
*Fusion and Docking inhibitorsin HIV
Enfurvatide
maviranoc
DR FUSION is trying to make his HIV AIDS MONSTER come to life by FUSING together a CD 4 TENNIS BALL and a HIV VIRUS while 2 superheros are preventing the FUSION and saving the wolrd
DR FUSION
CD 4 TENNIS BALLS FUSE with HIV VIRUS
make the HIV AIDS MONSTER
HERO 1 = MAVORIC who EJECTS from his MAVORIC JET and grambs onto the CROWN receptor of CD4 TENNIS BALL while his JET crashes into the GP 120 GRAPE on the VIRUS CELL
MAVORIC emergency ejectiona dn plane crash
EJECTION = grab to CROWN of CD4 TENNIS BALL
JET CRASH = GP 120 GRAPE on VIRUS CELL
HERO 2 = ENFUSION FRUITY MAN VIRUS STOPPER = pushes from inside the CD4 TENNIS BALL to stop the HIV getting through the GRAPE 41 cells and he also throws the GRAPE 41s behind him and they stick in the HAND of the person
ENFUSION FRUITY MAN VIRUS STOPPER
GRAPE 41
GRAPE 41 in the hand = sores at the injection site of ENFUSION FRUITY MAN VIRUS STOPPER
*Fusion
-
*Protease inhibitors
-
VIRUS PROPELLER ACE speed boat is winning the HIV VIRUS RACE when the NAVY gets CALLED in to bring their NAVIR NAVY GEAR to stop the VIRUS PROPELLER ACE
VIRUS PROPELLER ACE = protease inhibitors
NAVY CALLED in with NAVIR NAVY GEAR
the NAVY GEAR gets access onto the boat to attack because at the front of the VIRUS PROPELLER ACE BOAT is the CLEAVING HAPPY TIE LIVER CAT whose job it is to CLEAVE the PROTEINS of the NAVY GEAR
but the NAVY GEAR CHAINS the HAPPY TIE LIVER CAT and stops her from CLEAVING the PROTEIN CHAINS
the VIRS PROPELLER ACE is run by the BABY HIV VIRUS on the MOTOR side who gets CHAINED UP by the NAVY GEAR and can't GROW UP
VIRUS PROPELLER ACE MOTOR DRIVER = BABY HIV VIRUS
--> can't mature so STAYS a BABY HIV VIRUS on the VIRUS PROPELLER ACE boat
*Fusion
-
*Fusion
-
*Fusion
-
INTEGRA INTGRASE gets GRAVY GRAVIR poured on it when it is too loud in a town and DOESNT INTEGRATE well with NEIGHBOURS
INTEGRA INTEGRASE doesn't INTEGRATE with NEIGHBOURS
INTEGRA gets GRAVY GRAVIR poured on it to stop it
when the INTEGRA with GRAVY can't get going a HYPERLIPID HIKER dips his HYPERLIPID HIKERS in the GRAVY and the INTEGRA GRAVY spins its wheels and the LFT POILER gets HIGH and HOT
INTEGRA GRAVY = HYPERLIPID HIKER
INTEGRA GRAVY = HIGH LFT SPOLIER
the INTEGRA GRAVY pouring neighbour is INSOMIA GUY who can't sleep and runs out in his HIGH CK CALVIN KLEIN UNDERWEAR to pour the INTEGRASE GRAVY on the INTEGRA GRAVY CAR
INTEGRA GRAVY NEIGHBOUR = INSOMNIA GUY with HIGH CK CALVIN KLEIN UNDERWEAR
NEIGHBOUR 2 = HYPERLIPID HIKER GUY
*Fusion
-
*HIV Antivirals
recall HIV is pre MNOP RNA so it is
--> double stranded RNA
--> positive sense RNA