Protein Misfolding Diseases

Amyloid Diseases

Prion Diseases

Caused by

Amyloid B (AB)

which is

Extracellular component of Amyloid precursor protein

Caused by

Tau protein

which is

involved in microtubule construction

Neurofibrillary tangles and neurotoxicity

Neurofibrillary tangles and neurotoxicity

PrP protein

which is

expressed on surface of neurons and glial cells

Composed of Alpha Helixes

which become

Beta Sheets

Neurofibrillary tangles and neurotoxicity