Protein Misfolding Diseases
Amyloid Diseases
Prion Diseases
Caused by
Amyloid B (AB)
which is
Extracellular component of Amyloid precursor protein
Caused by
Tau protein
which is
involved in microtubule construction
Neurofibrillary tangles and neurotoxicity
Neurofibrillary tangles and neurotoxicity
PrP protein
which is
expressed on surface of neurons and glial cells
Composed of Alpha Helixes
which become
Beta Sheets
Neurofibrillary tangles and neurotoxicity