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Anaemia (Regenerative (Look at total protein (Normal (Haemolysis…
Anaemia
Regenerative
Look at total protein
Normal
Haemolysis
Intravascular
Extravascular
Hypoproteinaemia
Loss of whole blood
Trauma
Parasites
Coagulopathy
Non-regenerative
Anaemia present for >5 days?
No
Possibly too acute to see regeneration response
Yes
Chronic inflammation
Increased hepcidin will reduce ferroportin and prevent Fe uptake.
Renal disease
Reduced EPO causing reduced RBC synthesis
Bone marrow disease
Will have atypical cells in blood and pancytopaenia
Neoplasia
Space occupying lesion in bone marrow
Cytokine release and chronic inflammation