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Diseases (Autoimmune (celiacs (HLA (DQA1, DQB1, haploptypes DQ2.5 and…
Diseases
Autoimmune
celiacs
HLA
DQA1
DQB1
haploptypes DQ2.5 and DQ8
arthritis
lupus
MS
Type1 Diabetes
psoriases
Crohns
Alopecia
IBD
Nutritional Diseases
malnutrition
obesity
hyperglycemia
thyroid disorders
hypercholesterolemia
ApoB
LDLR
G6PD
Val68Met
Neurodegenerative diseases
Alzheimer's
Presenilins
Huntingtons
Htt
Parkinsons
alpha synuclein
Pink1
ALS
cOrf92
FTD
TDP43
FUS
Cancer
Subtype Drivers
Single Conserved Proteins
Co stimulation
Checkpoint
PD-L1
PD-L1
etc
4-1BB
CD28
Cancer Promoting Genes
BRCA 1/2
p53
KRAS
Conserved Human Proteins
CLLU1
C22ORF45
DNAH10OS
HSF1
Infectious Diseases
cytokine storms
IL-6
IL-22
IL-1B cascade
Inflammasomes
TNFa
antiviral immunity
tolerance
bacterial
Rare Diseases
Prader-Willis syndrome
beta thalessemia
macular degeneration
CFH (Y402H)
RMS2(A69S)
Hereditary
cystic fibrosis
CFTR
polycycstic kidney disease
PKHD1
tesachs
HEXA
Metabolic diseases
mitochondrial
Diabetes
type I
Type 2
IAPP
Typ3
antitrypsin
AAT/ Serpina1
microbiome diversity
secondary metabolites
Potential Effector Proteins
Nucleolus
p. granulous
Local production (tRNAs, ribosomes)
motor proteins
Prions
RBPs
on/off
scaffold
RNA aggregation
Base Modifiers
RNA
DNA
export machinery
RNA Degredation
RNAi
Proteasome
nonsense-mediated decay
nucleases
transcriptional repressors
transription factrs
DNA replication machinery
DNA Methylation/ Demethylation
speedu up/slow down transription
Chromatin Remodelers
On
Off
Cohesin
Closed to Chromatin --> Visa Versa
Splicing machinery
VH Options
Option 2
By effector mechansm
Base Editors
RNA modifiers (snoRNAs/methlyases)
DNA base editors
Upregulation
Transcription factors
Histone modifications
cohesin/open chromatin formation
Downregulation
Histone modifications
Chromatin-closing
RNA degradation
transcriptional repressor
proteasome
DNA methylation
Prions/Nucleoulus
Option 1
By Disease
Autoimmune
Inflammatory Processes
Nutritional
Rare/ Hereditry
Metabolic
ND
Cancer
Infectious Disease