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Viruses - RNA viruses (*RNA Viruses ALL RNA viruses are single stranded …
Viruses - RNA viruses
*RNA Viruses
ALL RNA viruses are
single stranded
--> compared to all DNA HHAPPPY viruses that are
double stranded
--> DNA exception = ssDNA Parvo virus
*After MnOP RNA viruses = Negative Sense / Helical RNA
*Rabies Virus = Rhabdovirus
similar pathophys to clostridium tetanus
--> rabies virus travels the same retrograde route of ACh
--> only difference is that rabies virus travels all the way to major structures of the CNS
hippocampus of Limbic system and Purkinje of cerebellum
--> affects Limbic System 5 Fs
--> Flight flight
must catch rabies early on in the infection before it becomes latent and reappears
--> biggest sign is intense itching at the bite/infection site
PHARYNGEAL SPASM
--> this is a classic sign of rabies
Limbic System + Rabies
hippocampus of Limbic system and Purkinje of cerebellum
--> affects Limbic System 5 Fs
--> Flight flight, feeding, feeling and sex
Cerebellum = affects inhbition from cerebellum
PathoPhys of Rabies
note that the rabies virus stays and replicates LOCALLY in your muscles for days or even weeks before it starts to travel retrograde to your CNS
--> this is the reason that it is extremely important to give prophylaxis Rabies vaccination if you have a suspected bite + prodromal fever symptoms
Clinical Presentation of Rabies
hydrophobia, photophobia
hippocampus
infection
--> aggression, personailty change
paralysis
painful spasms with swallowing or inspiration
--> gives the dysphagia
--> hydrophobia
--> aerophobia (fear of air)
RABBID RABBIT on RHINO brings his INTERNATIONAL GANG from SOUTH AMERICA and US to upper CANADA to try and infect the CANADIAN FEVER BEAVER
in RABBID RABBITS international gang are the SKUNK BAT from the US and the RABBID DOG from south america and everywhere else
--> common carriers of the RABBID RABBIT on RHINO VIRus
FEVER BEAVER uses everything in his power to fight off RABBID RABBITS GANG
he sprays WATER at the RABBID RABBITS GANG
--> this repels them a bit as they are hydrophobic
he then has the CANADIAN MOUNTIES shine a LIGHT on RABBID RABBITS GANG
--> since they are photophobic
all this does not work and the RABBID RABBITS GANG finally catch up with FEVER BEAVER since he is too slow because he is in a wheelchair
due to his paralysis
without any further help and treatment FEVER BEAVER dies from the RABBID RABBITS GANG
--> you die if you don't get treated fast enough
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RABBID RABBIT on RHINO is in the WILD WEST and is CHAAING ACh SEAGULL COLA receptor who stole HIS - ENVELOPED RNA VIRUS
when the RABBID RABBIT on RHINO finds the SEAGULL COLA receptor he tries to shoot him with a BULLET SHAPED RABBID RABBIT BULLET
--> RABBID RABBIT on RHINO is BULLET SHAPED
the RABBID RABBIT BULLET BACKFIRES though in a RETROGRADE fashion
--> RABBID RABBIT on RHINO travels RETROGRADE through SEAGULL COLA receptors and into things like the SALIVA GLANDS
--> this is how it infects people when animals bite them
the RABBID RABBIT doesn't give up that easy though, he HIRES a NIGERIAN BODY KICKING assassin to kick the SEAGULL with COLA right in the head
NEGRI BODIES are seen inside RABBID RABBIT onn RHINO infections
--> these are proteins from the rabies virus replicating inside cells
the NIGERIAN BODY KICKING assassin then spills BLACK INK BLOOD from the leaking SEAGULL COLA on his nice clean shoes
*Vaccines for Rabies
inactivated viral vaccine
part of
-->
"Salk Killed / RIP Always"
= dead vaccines
*Ebola / Filovirus Virus
part of the filovirus family
infects hepatocytes, endothelial cells and phagocytes
trasnmitted by bodily contact
E BOWLER DUDE FILES his NAILS, KNOCKS over BAT PINS and NEVER hits the SS LINEAR HELICAL GUTTERS
with his coach the RIGHTEOUS RHINO who collects the E BOWLERS checques for him in ENVELOPES
when E BOWLER DUDE is not bowling he is smoking MARLBOROS
Marburg virus is another type of FILOVIRUS
if E BOWLER DUDE ever step over the line and FOULS, people put a big NEGATIVE SIGN on his RNA LANE
E BOWLER DUDE is SS RNA negative sense
--> post MNOP = OAR MIXER FLUTE RHINO VIRUS
--> post MNOP = PARACHUTE FLUTE to the neglecting BARKING SEAL PARENTS
Ebola Course of Infection
incubation = 10 days on average
--> can range from 2 to 21 days
starts with flu like symptoms
ends with bleeding from everywhere basically
echymosis from internal bleeding
mucosal membrane bleeding
hemoptysis and hematomeses
internal bleeding is what kills you
E BOWLER dude steps outside the 10 PINs BOWLING ALLEY when he finds his friend got beat up by the rival bowlers and gave him FLU like symptoms
*Paramyxoviruses = MMR
parainfluenza
RSV = respiratory syncytial virus
Measles, Mumps, (Rubella = German's measles is technically not a meales virus, it is a pilovirus)
MMR cause "croup COFF"
--> barking seal cough
--> caused by F = fusion protein
MEasles = Rubeola virus
*Parainfluenza = Croup in Paramyxoviruses
MMR cause "croup COFF"
--> barking seal cough
--> caused by F = fusion protein
PARENTS with CROUP = BARKING SEAL PARENTS that just sit and EAT their own CROUP CREPES and don't share any of it with the BABY
the BABY doesn't get fed any of the CROUP CREPE by her BARKING SEAL PARENTS and decides to just INHALE from a PIPE she found on the ground that INHALES right into her STRIDER STROLLER
PARAFLUTE VIRUS has
--> CROUPE CREPES
--> BARKING SEAL PARENTS
--> INHALING STRYDER STROLLER
the baby dies from this inhation to her STRIDER STROLLER and is buried at the CHURCH STEAPLE
CHURCH STEEPLE SIGN is common on XRAY of the LARYNX in kids with PARACHUTING FLUTE VIRUS CROUP
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*Measles = RUBEOLA VIRUS
MMR cause "croup COFF"
--> barking seal cough
--> caused by F = fusion protein
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*Mumps
MuMPs = makes Paramyxo
"POM POM LUMPs in your MUMPS"
--> out of your parotids, orchids (testes), meninges and pancreas
MMR cause "croup COFF"
--> barking seal cough
--> caused by F = fusion protein
MUMMY with HUMPS CAMEL VIRUS and his gang of SCEPTOR MEN IN TIGHTS are trying to overthrow the KING PHAROH PARROT PAROTIDS on FIRE
KING PHAROH PARROT PAROTIDS on FIRE always wears his GOLD AMYLOID chain NECKLACE that hangs from his FLAMING PARROT PAROTIDS on FIRE
MUMMY HUMPS CAMEL VIRUS presents with
--> PARROT PAROTIDS ON FIRE
--> raised GOLD AMYLASE NECKLACE levels
MUMMY with HUMPS CAMEL VIRUS and his gang of SCEPTOR MEN IN TIGHTS start by throwing a TESTICLES on FIRE at the PHAROH PARROT PAROTIDS on FIRE
unique sign of MUMMY with HUMPS CAMEL VIRUS = orchitis = inflammed and sore testicles or ovaries
the PHAROH PARROT PAROTIDS on FIRE then catches her PANCREAS on FIRE as well fromt he FLAMING TESTICLES and he is defeated
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Adult Mumps and *POM POM complications
POM = swelling and lymphadenopathy
--> starts in POM = Parotids and moves to POM POM
POMs
--> Pancreas
--> orchiditis
--> meninges
atrophy of the semiferous tubules is serious in MUMPS POM POM
--> may haveto tx with testosterone
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*RSV = Respiratory Syncytial Virus
one of the PaRa Myxoviruses
SYNDYCATE BOSS called BABY FACE is in his GETAWAY RV the Super SRV
BABY FACE in SUPER RV is being chased after leaving the RTI he just caused
BABY FACE throws his bottle on the road to try and stop the COPIUS MUCUS COPS and WHEEZLE CANINE unit
--> poor feding in RSV is a main symtpom
BABY FACE in SUPER RV is being chased by COPIUS MUCUS COP. WHEEZLES the CANINE unit dog
BABY FACE in SUPER RV causes wheezing, copius mucus production that clogs up the bronchioles
CONVICT on FIRE GUY with OATS OTTITIS EARS drops TACHS on the ground that TACHYPNEA COP slips on
RSV causes tachypnea since the babies can't breathe from all the mucus they produce
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RSV Treatment
prophylaxis tx = POLICE VESPA =
palivizumab
--> prophylaxis has to be given to babies born premature < 29 weeks until they reach age 1
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Clinical Cases
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PARACHUTING MIXER held up by CYLINDER HELIXES and driven by the RNA RHINO that are going twoards the SEA to retrieve an ENVELOPE they LOST
paramyxoviruses are ENVELOPED
the envelope was actually stolen by a SURFING MEASLE
--> PARACHUTE MIXER VIRUSES = MEASLES MMR
the SURFING MEASLE was on a SURF board FUSED to MUltiNUCLEAR SHELLS
--> fusion proteins of paramyxos cause multinuclear cells to develop
*Orthomyxovirus = Influenza Virus
treatments:
oseltamavir = Tamiflu
--> must be given within 2 days of onset
--> lowers the severity and course of the virus
Post Influenza Secondary bacterial infections
SSH big bacteria causes
--> strep pneumo, staph a., hemophilus influenzae
Influenza Vaccine
2 types
IM injection = Inactivated / killed vaccine
Influenza IM vaccine
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Nasal Spray = live attenuated (can't infect) vaccine
Pathophys
h1n1
h =
hemaglutinin
--> allows viruses to attach to host cells and gain access
n =
neuraminidase
--> allows viruses to cleave from the host cell, spread and infect
Clinical presentation
fast onset!
--> within 24 hours
non-productive cough
fever / pyrexic
malaise
myalgia
Influenza Treatments
:
normally influenza is not treated since self limiting and treatment only shortens symptoms by about 1 day? - confirm this
treatment is indicated for elderly or young people
oseltamivir (Tamiflu)
note that oseltamivir = Tamiflu must be taken within 48 hours of symptom onset in order for it to lesson the length of infection
"OH SELL IT on the mountains"
--> oseltamivir stops influenza for old Tibetan monks
FLUTE VIRUS sits on his RNA RHINO waiting in his CAVE and plays the FLUTE plus OARS MIXER to SCARE his VICTIMS
FLUTE VIRUS on RNA RHINO = Influenza Virus
FLUTE VIRUS on RNA RHINO uses the OARS MIXER
--> Orthomyxovirus
the FLUTE VIRUS on RNA RHINO with OAR MIXER noise CAVE on one end has HANGING GLUE and HAM to try and lure victims into the CAVE
Hemagluttinin of FLUTE VIRUS on RNA RHINO
On the other END of the CAVE there are NEURONS with DAISES that have been able to escape the CAVE
Neuraminidase of FLUTE VIRUS on RNA RHINO
in the CAVER the main victim = GREEN BERET MAN
GREEN BERET MAN always has some kind of motorization because he loses myelin in his legs first
--> wheelchair (CAMP CAMPYLOBACTOR JEJUNI 42 DEGREES)
in the FLUTE VIRUS on RNA RHINO CAVE GREEN BERET MAN is riding an 8 BALL SEGUEY with a HELICAL shaped HANDLE BARS
FLUTE VIRUS on RNA RHINO with OAR MIXER has 8 SEGMENTS in its RNA that allows it to mutated and recombine easily with other viruses
GREEN BERET MAN can't see in the cave and he would have been FUCKED if it weren't for his REYES ASPIRIN bottle with REYES of light
--> REYES syndrome in kids (hepatomegaly with fat deposits) from giving ASPIRIN to kids with FLUTE VIRUSmeasle
*Coronavirus = Common cold and SARS
"common cold CURED with
CORONA
"
--> the common cold is part of the corona family of viruses
CROWN CORONA VIRUS is hard to distinguish from the
RHINOvirus
of the picoRNA viruses =
PERCH
family
--> both are very similar
--> only difference is the SARS strain that can enter the LOWER RTI and also enter the GI tract for gastroenteritis
*SARS - coronavirus subtype
SARS = SEVERE acute respiratory syndrome
CROWN VIRUS rides in on RNA RHINO to take over the ZSARS russian kingdom and infects all the COMMONER with a COMMON COLD
the henchmen of CROWN VIRUS take over SARS KINGDOM are RNA RHINOS that deliver ENVELOPES to COMMON peasants and arrest them
the ZSAR of the kingdom flees and doesn't protect the COMMON PEOPLE because he himself comes down with a SEVER version of the CROWN VIRUS called SARS VIRUS
*Before MnOP RNA viruses = Positive Sense / Icosahedral RNA
Positive Sense includes main group of
"Positive picoRNA PERCH viruses"
--> Rhinovirus and HAV
Positive / before MnOP viruses also includes most common HAV and HCV
-->
HAV
part of
picoRNA PERCH
-->
HCV
part of coloured yellow/black
DINGUES in West Nile River
*Picornavirus family
"picoRNA viruses PERCH"
--> poliovirus
--> Echovirus
-->
Rhinovirus
--> Coxxsackie virus (palate petechiae)
-->
HAV
*Rhinovirus
cause of the common cold
"picoRNA viruses PERCH"
--> poliovirus
--> Echovirus
-->
Rhinovirus
--> Coxxsackie virus (palate petechiae)
-->
HAV
Rhinovirus invades by
ICAM-1 (CD54)
receptors
-->
ICAM1
= intracellular adhesion molecule-1.
RHINOVIRUSES are COMMON COLDS so they NUMBER in the HUNDREDS
RHINOVIRUSES = COMMON COLD
they WAIT in LINE at the stomach to try and gain entry
but the STOMACH has many other PICKLED CORN VIRUSES that have gained entry all ready so it NEVER lets in the LONG LINE of COMMON RHINOVIRUSES
the STOMACH uses its stores of PICKLED CORN VIRUS to porr ACID on the RHINOVIRSUS WAITING in LINE
--> this kills them so they NEVER get entry intot he stomach like the other PICKLED CORN VIRUSES
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Clinical Cases
Clinical Case
Notes
:
note that
Clinical Case
Picornavirus
Notes
:
note that all picornaviruses are enteroviruses
--> exception is rhinovirus is NOT an enteroviruses
note that over 90% of viral meningitis are enteroviruses
Case presentation:
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the PICKLE CORN HARVEST VIRUS in the garden of the ICE CATHEDRAL where the POPE sits in his PERCH and gives the signal for the PICKLED CORN HARVEST VIRUS to begin
icosahedral shape
PICKLED CORN HARVEST POPE = POPE PERCH
the PICKLED CORN VIRUS HARVEST starts with a bang when the NUNs with ENVELOPS come riding out of the ICE CATHEDRAL to tell all the animals they can start PICKING
NUN ENVELOPED
the NUN ENVELOPES are riding on RNA RHINOS and CLEAVE through the SINGLE POLYPEPTIDE CHAIN to start the VIRUS OFF
--> RNA RHINO viruse
--> SINGLE POLYPEPTIDE CHAIN is the RNA for the virus that gets cleaved into its proteins
ALL the contenders for the PICKLED CORN HARVEST VIRUS come out into the field
the HAPPY TIE APPLE and PICKLE STAND GUY tries to stop them because he wants them to buy APPLES and PICKLED CORN from his stand instead
--> but he gets run over by the NUN ENVELOPES riding on their RNA RHINOS
the RHINOVIRUS is the first to the PICKLED CORN HARVEST since he has an in with the NUN ENVELOPES and RNA RHINOS
next the POLIOVIRUS rides in on his HORSE PLAYING POLIO
the POLIOVIRUS SACKS a COXSACKIE COCK VIRUS to get to the PICKLED CORN HARVEST FIRST
meanwhile the ECCHO VIRUS yodles from the other field across the road to declare an all out WARFARE between the PICKLED CORN FARM and the APPLE FARM when he sees that they ran over their leader = HAPPY TIE APPLE = PICKLED CORN STAND GUY
they send in their MEN IN TIGHTS to fight the BATTLE
*COXSACKIE VIRUS
divided into two types
--> COXSACK VIRUS 1 = Hand foot and mouth disease
--> COXSACK VIRUS 2 = viral MYOCARDITIS
COXSACKIE A VIRUS = *Hand foot and mouth disease
COXSACK VIRUS 1 = Hand foot and mouth disease
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COXSACKIE B VIRUS = viral *MYOCARDITIS
COXSACK VIRUS 2 = viral MYOCARDITIS
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COXSACKIE VOLLEY BALL GAME betweent the 2 COCK SACK teams = the better HAND FOOT MOUTH DIGGERS who are the MEN IN TIGHTS who TRAIN all LATE SUMMER / vs the terrible and LAZY TYPE 1 DYED BEAD PANCREAS hold a HEPATOMEGALY BALLON in ONE hand and a MYOCARDITIS CARD in the other hand
HAND FOOT MOUTH DIGGERS who are the MEN IN TIGHTS who TRAIN all LATE SUMMER
COCK SAX 1 team = hand foot and mouth disease
COCK SAX 1 team = ASEPTIC MEN IN TIGHTS
--> this is normally during LATE SUMMER
the terrible and LAZY TYPE 1 DYED BEAD PANCREAS hold a HEPATOMEGALY BALLON in ONE hand and a MYOCARDITIS CARD in the other hand
COCK SAX 2 team = TYPE 1 DYED BEADS PANCREAS
COCK SAX 2 team = VIRAL MYOCARDITIS
COCK SAX 2 team = HEPATOMEGALY BALLOON
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*Flavivirus family
transmitted by mosquitos
"YELLOW and BLACK COLOURED DINGIES in the West Nile river give you ZIKA"
-->
"FLAVI
= yellow fever triad with jaundice, fever and black vomit
-->
"COLOURED DINGUE"
HCV and Dengue fever
-->
'WEST NILE river ZIKA"
= west nile and Zika are flaviviruses
*Dengue Fever virus
transmitted by mosquitos
"YELLOW and BLACK COLOURED DINGIES in the West Nile river give you ZIKA"
-->
"FLAVI
= yellow fever triad with jaundice, fever and black vomit
-->
"COLOURED DINGUE"
HCV and Dengue fever
-->
'WEST NILE river ZIKA"
= west nile and Zika are flaviviruses
Primary vs Secondary Dengue Fever Infection
note that your primary Dengue fever infection can be non-lifebthreatening and self limiting
but your secondary infection can be more serious and can also be from a different serotype of Dengue
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*West Nile Viirus
transmitted by mosquitos
"YELLOW and BLACK COLOURED DINGIES in the West Nile river give you ZIKA"
-->
"FLAVI
= yellow fever triad with jaundice, fever and black vomit
-->
"COLOURED DINGUE"
HCV and Dengue fever
-->
'WEST NILE river ZIKA"
= west nile and Zika are flaviviruses
*Zika virus
transmitted by mosquitos
"YELLOW and BLACK COLOURED DINGIES in the West Nile river give you ZIKA"
-->
"FLAVI
= yellow fever triad with jaundice, fever and black vomit
-->
"COLOURED DINGUE"
HCV and Dengue fever
-->
'WEST NILE river ZIKA"
= west nile and Zika are flaviviruses
*YELLOW fever BEAVER symptoms
YELLOW FEVER BEAVER is sentences by ENVELOPE from teh ICE CATHEDRAL to walk the PLANK to HADES MOSQUITO after he had a DEMONIC YELLOW FEVR BEAVER BLACK VOMMITING episode in the ICE CATHEDRAL CONFESSIONAL
YELLOW FEVER BEAVER = has DEMONIC black vomit
FLAVA FLAVE is the SLAVE at the ICE CATHEDRAL whose job is to push DEMONIC FEVER BEAVERS off the PLANK and down into the ICE WATERS below
YELLOW FEVER BEAVER = ICE CATHEDRAL FLAVA FLAVE SLAVE VIRUS
the ICE CATHEDRAL FLAVA FLAVE VIRUS is also the JAUNDICE JANITOR who mops up the FEVER BAVER BLACK VOMIT
when YELLOW FEVER BEAVER falls into the ICE WATERS below he is brought in a MONKEY AND HUMAN RESEVOIRE row boat down the river stix and to the HADES MOSQUITO to be trasnferred as a YELLOW FEVER BEAVER DEMON into another poor human soul above
the YELLOW FEVER BEAVER DEMONIC BLACK DEMON VIRUS is a continuoous cycle between
ICE CATHEDRAL FLAVA FLAVE SLAVE JAUNDIC JANITOR
MONKEY HUMAN ROW BOAT
HADES ADES MOSQUITO
*Rotavirus = Reovirus
"Rang up the COPS on the ROTA to confess: I shot a man in REO"
most common cause of
watery diarrhea in children < 4
ds RNA, no envelope
not as common anymore if kids are vaccinated
most adults are either vaccinated or have immunity due to exposure
SEGMENTED virus
--> part of
"BOAR"
viruses that BOAR in together and mate...
--> reason why it can cause a huge outbreak in a daycare
ROTA PHONE DOUBLE STRANDED RNA RHINOS establish a NEW ICE CATHEDRAL CHURCH in REO DE JENERO to replace the catholic church there
ROTA REO VIRUS with ICE CASTL CATHEDRAL built by invading RNA RINOS
--> double stranded RNA RHINOS
when the church invaded and took over all the CATHOLICS, a NUN sent an ENVELOPE LETTER to the pope to call for help
--> ROTA REO ICE CASTLE RNA RINO VIRUS
--> does not have an envelope = NUN ENVELOPE
RNE RINO ROTA REO VIRUS spread their church established in REO to take over the whole world and give all the KIDS at DAYCARE WORLDWIDE WATERY DIARRHEA
ROTA REO virus is the highest cause of watery viral diarrhea in the world
TX for ROTA REO DOUBLE RHINO virus in ORAL REHYDRATION
the NUNs taking care of all the daycares in REO BRAZIL and the daycares worldwide gave the kids ORAL REHYDRATION THERAPY
*NOROvirus
common cause of viral gasteritis
part of
--> PAPP smear and CPR to NAKED HIPpies
--> non-enveloped
CHUCK NORRIS VIRUS travels around the world on his CRUIZE SHIP with KALISEE and helping the CATHOLIC CHURCH kick the ASSES of people who SPILL the wine of the KALESSI CHALACE
CHUCK NORRIS NOROVIRUS = KALEESI CALICI virus
this time they go to the ICE CATHEDRAL CHURCH on their CRUIZE SHIP where a NUN with ENVELOPE of an RNA RHINO points to him since he spilled the wine from the KALEESI CALICI CHALLACE in the ICE CATHEDRAL CHURCH
NUN enveloped
RNA RHINO virus
KALEESI CALCI virus
CRUIZE SHIPS
there is no treatment for CHUCK NORRIS NOROVIRUS since mds don't treat CHUCK NORRIS VIRUS he treats MEDS!
supportive tx ONLY for CHUCK NORRIS VIRUS
you just have to sit on the ACUTE FLUSHER TOILET to recover from his round house kick to the face
*Togaviruses
"NO togas or Tolgas in Germany!!! No BELLS in Germany either! NO FUN!"
chikungunya Aedes virus
*Rubella = German's Measles = Togavirus family
very similar presentation to Measles of MMR, but characteristic posterior auricular lymphadenopathy is the start of the facial rash that spreads to the lower trunk and limbs
--> compared with the KOPLIK spots in the sublingual area of measles
--> same rash spread though
note that Rubella even though looks very much like Measles and MMR of Paramyxo (-)
--> rubella is actually PRE MNoP Myxo = (-) RNA viruses
--> Rubella is SS RNA + srand
Memory mnemonics
RED BELL REBELLION RUBELLA is the story of GERMAN MEASLES and RNA RHINO who stole secrete ENVELOPES from the ICE CATHEDRAL
the sound of the RED BELL REBELLION GERMAN MEASLES VIRUS made the POST AURICULAR EARS of KING ARTHUR ARTHRITIS RING
then he got a RASH that SPREAD DOWN from his EARS to the rest of his body
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RED BELL REBELLION MEASLES TORCH INFECTION
Rubella TORCH infection in babies
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*congenital Rubella
Classic Triad
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*Rubella Vaccine
live attenuated
--> part of
"Music LYRICSS are LIVE!"
--> MUSIC = MMR
*Chikungunya
chikungunya Aedes virus
Clinical Cases
Clinical Case
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*Positive sense vs Negative sense
sense stranding = CODING strand
--> if + sense strand RNA
--> means it can be read by RNA dependent RNA POL to make proteins right away
antisense = TEMPLATE strand
--> this is the original strand of DNA so CANNOT be made into proteins right away
*Home
