*HHV = Human Herpes
Virus Family

• 8 subtypes
• go in order of importance
  --> HSV 1/2 (mouth/genitals)
  --> VZV (varicella/zoster shingles)
  --> HHV4 = EBV (infectious mono)
  --> HHV5 = Cytomegaly virus (SIGHTO / immuno suppress)
• Double stranded and enveloped DNA virus family
  --> think HHV has Double HH protection + enVeloped hhV
• HSV1 / HSV2 = "FIRST you KISS, 2nd you FUCK"
  --> HSV1 = oral cavity + cribiform plate (herpes labialis = cold sore)
  --> HSV2 = genitals (herpes genitalis)

*COMMON HHV - Healthy people HHV Viruses

• includes HHV 1 - 4
• HSV- 1 and 2
• VCV - kids = Varicella chicken pox
• VCV - elderly = Zoster shingles
• HHV 4 = EBV = Ebstein Barr virus = mononucleosis in teens

*HIV / Immunosupressed HHV Viruses

• includes HHV 5 - 8
• HHV 5 = CMV
  --> (one of the most common infections in HIV people)
• HHV 6/7 = Infant ROSEOLA Herpes Virus
  --> ("ROSEOLA = fever first, ROSY cheeks LATER")
• HHV 8 = Adult Kaposi Sarcoma Herpes
  --> Kaposi sarcoma = neoplasm of endothelial cells

*Kaposi Sarcoma HHV 8 Viruse

• HHV 8 = Adult Kaposi Sarcoma Herpes
  --> Kaposi sarcoma = neoplasm of endothelial cells

*ROSEOLAS Infant HHV 6/7 Viruse

• HHV 6/7 = Infant ROSEOLA Herpes Virus
  --> ("ROSEOLA = fever first, ROSY cheeks LATER")
  

*HSV 1
(Herpes Simplex Virus 1)
(cold sores)

• HSV1 / HSV2 = "FIRST you KISS, 2nd you FUCK"
  --> HSV1 = oral cavity + cribiform plate (herpes labialis = cold sore)
  --> HSV2 = genitals (herpes genitalis)
• HSV1 / HSV2 = "ONE BRAIN, 2 MENINGES"
  --> HSV1 = encephalitis
  --> HSV2 = meningitis
• HSV1 = most common cause of sporadic encephalitis
• HSV1 gives you 2 TEMPORARY things:
  --> " TEMPORARY LABLIAS and TEMPORAL LOBE enchepalitis
  --> Herpes labialis
  --> HSV1 most common cause of sporadic temporal enceph in young people

*HSV 2
(Herpes Simplex Virus 2)

• HSV1 / HSV2 = "FIRST you KISS, 2nd you FUCK"
  --> HSV1 = oral cavity + cribiform plate (herpes labialis = cold sore)
  --> HSV2 = genitals (herpes genitalis)

*Tzank test for HSV

• "TZANK Heavens I don't have HERPES"
• Tzank smear of HSV-1 ulcers shows giant cells that are multinucleated

*PHN = Post herpetic Neuralgia treatment

• happens weeks to months after having shingles or reactivation of VZV
• 1st line = TCAs, pregabalin and gabapentin
• 2nd line = lidocaine patch, topical capsacin
• "TRY Trys and GABAs first in BURNING neuropathic pain... before you TRY oppening a LID of HOT PEPPERS on it".
  --> TRY Trys and GABAs = 1st line TCA and gabapentin
  --> LID of HOT PEPPERS = 2nd line lidocaine and capsaicin

HSV Encephalitis Differential Pathogens

• note that toxoplasmsis and CMV can both cause encephalitis, but usually ONLY in HIV and immunocompromised people

MONKEY NUCLEAR PLANT poisons the SMALL TOWN LAKE and makes the ANIMALS and CREATURES in the lake MUTATE and attack the TOWNS PEOPLE

• first a HERPES HARP = 4/5 emerges from the MONKEY NUCLEAR LAKE and makes a YOUNG TEENAGER very SLEEPY
• 2nd a FEAVER BEAVER comes out of the MONKEY NUCLEAR LAKE and punches a girl in the head and back to give her many ACHES
  
  

then next the SUPERHERO = SWOLLEN LIMES in ARMPITS and NECK MAN comes floating down on his INFLATED HEPATOMEGALY BALOON and SPLENOMEGALY BALLOON

• SUPERHERO SWOLLEN LIMES in ARMPITS and NECK MAN then throws his SWOLLEN LIMES at the MONKEY NUCLEAR plant and kills the MONKEY
• the MONKEY emerges from the wreck with a large RASH all over his body
  --> diffuse rash happens in EBV when people with MONO / EBV think they have a STREP throat infection and take amoxacillin
  --> they then get a huge diffuse rash on their body
  
  

at the end of the MONKEY NUCLEAR plant SAGA the MONOCYTE MAYOR of the small town gives SUPERHERO SWOLLEN LIMES in ARMPITS and NECK a MONOSPOT + certificate
--> MONOSPOT + test for EBV
--> note this is NEGATIVE for CMV type MONO

HERPES HARP GATES of DS DNA

• HSV1 HERPES HARP GATE sit on top of a TEMPORAL ENCEPHALITIS
  --> HSV1 most common cause of PSORADIC ENCEPHALITIS
• HSV2 HERPES HARP GATE was built by MEN IN TIGHTS

HERPES WEDDING with HERPES HARP and GENITAL GENTLEMAN bring their parents APPLE CYCLOPS and VEIL CYCLOPS when they ar walking down the aisle FAN CYCLOPS blows wind into HERPES HARPS hair

VARCITY ZORRO VIRUS was a hero in highschool who saved the NUDE MONA painting from ENCAPHALITIS CHICKEN the older man who caught PRIMARY VARSITY ZORRO VIRUS

• VARSITY ZORRO VIRUS also wrecked the ENCAPHALITIS CHICKENS roof by throwing a MULTINUCLEATED SHELL that tore off all the SHINGLES of ENCEPHALITIS CHICKENS house

CHICKENBOX at her first day of school gets VZV and gets shoved into a locker where she meets a SECRET SOCIETY that gather around the table of CENTRAPEDAL POSTER RASH

EINSTEIN BAR VIRUS is double stranded DNA LIMBO BAR with the MONONUCLEOSIS MONKEY holding the PRIZE money in the ENVELOPE

the MONONUCLEOSIS MONKEY is very talented and is holding the PRIZE MONEY ENVELOP in one HAND and in the other a BASKETBALL with CD21 BLACK JACK CARDS

• EINSTEIN BAR VIRUS gets into B cells through the CD 21 marker
  
  

CANCERS associated with EINSTEIN BAR DISEASE

• NASO PHAROAH in CAR WITH GNOME are throwing LIMES at the MONONUCLEOSIS MONKEY and trying to knock him over from their BUCKET OF LIME FOAMS
  --> EINSTEIN BAR VIRUS can give NASOPHARYNGEAL CARCINOMA
  --> also BURKIT B CELL LYMPHOMA
• there is the LION KING HOG KING also with LIME FOAMS
  --> EINSTEIN BAR VIRUS causes HODGEKINS LYMPHOMA

HOG KING with LIME FOAMS = HODGEKIN's LYMMPHOMA

SIDE TOE VIRUS runs the TRAINS PLANTS DNA Railroad car carrying the special delivery of LETTERs and ENVELOPES filled with the NUDE pictures of JAN IN JAMAICA GANCYCLOVIR

• SIDETOE MEGALO TRAINS PLANTS is an eveloped DS DNA virus
  
  

the TRAINS PLAINS has a HERPES HARP as a train whistle and OWLS EYE INCLUSION lights to make sure they know where they are going

the OWLS EYE INCLUSION lights are not bright enough to see the DS DNA track

they can't see anything at all

• so SIDE TOE driving the TRAINS PLANTS puts his BABY on the front of the TRAINS PLANTS and gives hima TORCHES to hold to light the DNA TRACK
• but he still can't see...
  
  

just then the SIDE TOW driving the TRAINS PLANTS gets distracted by a NUDE MONA picture of JAN in JAMICA JANCYCLOVIR and runs over a BAND AID and RED EYES on a SARCOPHAGUS ESOPHAGUS and

• Gancyclovir = 1st line tx for SIDE TOE TRAIN PLAINS

Tx of CMV

• 1st line = GANCYCLOVIR
  --> special delivery by the SIDE TOE driving the TRAINS PLANTS on DNA TRACK carrying ENVELOPES filled with
• NUDE PICS of JAN IN JAMIACA GANCYCLOVIR
  

SIDE TOE CHANDELIER MTV CRIBS in the UTERUS with the TORCHES on the WALLS and the PARIED VENT CALFICATION COW pouring milk onto all the DESSERTS

the HEADPHONES are so big and LOUD tha they shrink the BABYS head

• EARPHONES = deafness
• holoprosencephaly
  
  

DESSERTS on the luxurious table at SIDE TOEs CHANDELIER MTV CRIBS uterus

• PAIRED VENT CALCIUM COW
  --> SIDE TOE CHANDELIER TORCHES = periventricular calcifications
• blueberry muffin RASH
  --> SIDE TOE CHANDELIER TORCHES = blueberry muffin RASH
• TIKI MASK RASH
  --> SIDE TOE CHANDELIER TORCHES = petechial rash
• OREO on RED TIN
  --> SIDE TOE CHANDELIER TORCHES = chorioretinitis
  

*Mononucleosis in EBV vs CMV

• EBV mono is Monospot +
• CMV mono is Monospot -
• Monospot test tests whether the virus agglutinates horse erythrocyte or not

*Heterophile MONOSPOT test for diagnosing EBV vs CMV

• tests whether EBV infected B cells can agglutinate with heterophile titers to horse erythrocytes

ROSELOA ROSY O OLYMPICS for BABIES where they try to swing through the big ROSY O

• ROSEOLA ROSE O virus = seen in babies
• ROSEOLA ROSE O ring sits on top of the DS DNA columns
  
  

the BABY beats the FEVER BEAVER by using her cheat sheets in her ENVELOPE and counterbalancing himself by hanging a HERPES HARP with a 6 SAXAPHONE on it

ROSEOLA game is the second competition in the ROSEOLA OLYMPICS after the ROSEY O ROSE RING - this time it is a

this is the ROSEY O and COLLESUEM X TIC TAC TOE game for BABIES

• ROSEOLA INFANTUM
  
  

ROSEOLA ROSE O COLLOSEUM TIC TAC TOE champion beat the FEVER BEAVER in the COLLOSEUM ROSEOLA TIC TAC TOE game in fron of the whole crowd

• the SEIZURE CESAAR gives the thumbs down for FEVER BEAVER to be shot out of the COLLOSEUM in the HERPES HARP 6 SAXOPHONE shooter
  --> ROSEOLA ROSE TICC TAC TOE COLLOSEUM = HERPES 6
• the MAC PAP MOB is the crowd and they cheer, but the NUN puritic NUN quiets them down
• SEIZURE CESAR then gives the THUMBS down and FEVER BEAVER is shot out of the ROSEOLA TIC TAC TOE COLLOSEUM
  
  

meanwhile SEIZURE CESAR takes a soak in his BATH with BETTY BOOP IBUPROFEN when suddenly some schemers in the assembly kill him by putting a A CHEETAH with a FIN ACETAMINOPHIN in the bath with him