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Viruses - HHV Family (*HHV = Human Herpes Virus Family 8 subtypes go…

- - - - HHV-4
        (*EBV = Epstein-Barr Virus)
        
        Ebstein Barr Virus
        --> Bcells CD 21
        --> Burkitt Lymphoma
        
        Notes:
        
        almost 90% of the population has EBV by their late teens, though many infections are unsymptomatic
        
        HH4 EBV BURKIT LYMPHOMA
        
        Ebstein Barr Virus
        --> Bcells CD 21
        --> Burkitt Lymphoma
        
        Clinical Cases
        
        Clinical Case
        
        Notes:
        
        note that
        
        Clinical Case
        
        Infectious Mononucleosis (Mono) and Reactive Lymphocytes
        
        secondary to EBV usually
        
        reactive macrophages release perforin and granzymes
        
        granzymes = granular enzymes = grandiose apoptosis
        
        Clinical Case
        
        Notes:
        
        note that Infectious mononucleosis from EBV are reactive cytotoxic lymphocyte = mostly natural killer cells and t cells
        
        they have cytotoxic granuoles = perforin and granzymes
        
        *INfectious Mononucleosis
        
        caused by both EBV and CMV
        --> HHV 4 + HHV 5
        
        note that CMV MONO is monospot NEGATIVE
        --> NOT picked up by the MONOSPOT TEST
        
        MONKEY NUCLEAR PLANT poisons the SMALL TOWN LAKE and makes the ANIMALS and CREATURES in the lake MUTATE and attack the TOWNS PEOPLE
        
        first a HERPES HARP = 4/5 emerges from the MONKEY NUCLEAR LAKE and makes a YOUNG TEENAGER very SLEEPY
        
        2nd a FEAVER BEAVER comes out of the MONKEY NUCLEAR LAKE and punches a girl in the head and back to give her many ACHES
        
        then next the SUPERHERO = SWOLLEN LIMES in ARMPITS and NECK MAN comes floating down on his INFLATED HEPATOMEGALY BALOON and SPLENOMEGALY BALLOON
        
        SUPERHERO SWOLLEN LIMES in ARMPITS and NECK MAN then throws his SWOLLEN LIMES at the MONKEY NUCLEAR plant and kills the MONKEY
        
        the MONKEY emerges from the wreck with a large RASH all over his body
        --> diffuse rash happens in EBV when people with MONO / EBV think they have a STREP throat infection and take amoxacillin
        --> they then get a huge diffuse rash on their body
        
        at the end of the MONKEY NUCLEAR plant SAGA the MONOCYTE MAYOR of the small town gives SUPERHERO SWOLLEN LIMES in ARMPITS and NECK a MONOSPOT + certificate
        --> MONOSPOT + test for EBV
        --> note this is NEGATIVE for CMV type MONO
        
        EINSTEIN BAR VIRUS is double stranded DNA LIMBO BAR with the MONONUCLEOSIS MONKEY holding the PRIZE money in the ENVELOPE
        the MONONUCLEOSIS MONKEY is very talented and is holding the PRIZE MONEY ENVELOP in one HAND and in the other a BASKETBALL with CD21 BLACK JACK CARDS
        
        EINSTEIN BAR VIRUS gets into B cells through the CD 21 marker
        
        CANCERS associated with EINSTEIN BAR DISEASE
        
        NASO PHAROAH in CAR WITH GNOME are throwing LIMES at the MONONUCLEOSIS MONKEY and trying to knock him over from their BUCKET OF LIME FOAMS
        --> EINSTEIN BAR VIRUS can give NASOPHARYNGEAL CARCINOMA
        --> also BURKIT B CELL LYMPHOMA
        
        there is the LION KING HOG KING also with LIME FOAMS
        --> EINSTEIN BAR VIRUS causes HODGEKINS LYMPHOMA
        
        HOG KING with LIME FOAMS = HODGEKIN's LYMMPHOMA
        
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        *Heterophile MONOSPOT test for diagnosing EBV vs CMV
        
        tests whether EBV infected B cells can agglutinate with heterophile titers to horse erythrocytes
        
        HHV-3
        (*VZV= Varicella-Zoster Virus)
        (chicken pox / shingles)
        
        Notes:
        
        primary V-Z virus = chicken pox
        
        secondary V-Z virus = shingles
        
        *Zoster virus = Shingles
        
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        *Varicella virus = Chicken Pox
        
        CHICKENBOX at her first day of school gets VZV and gets shoved into a locker where she meets a SECRET SOCIETY that gather around the table of CENTRAPEDAL POSTER RASH
        
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        VARCITY ZORRO VIRUS was a hero in highschool who saved the NUDE MONA painting from ENCAPHALITIS CHICKEN the older man who caught PRIMARY VARSITY ZORRO VIRUS
        
        VARSITY ZORRO VIRUS also wrecked the ENCAPHALITIS CHICKENS roof by throwing a MULTINUCLEATED SHELL that tore off all the SHINGLES of ENCEPHALITIS CHICKENS house
        
        HSV type 1 and 2
        
        Tzank test for antigens
        
        "TZANK Heavens I don't have HERPES"
        
        *HSV 1
        (Herpes Simplex Virus 1)
        (cold sores)
        
        HSV1 / HSV2 = "FIRST you KISS, 2nd you FUCK"
        --> HSV1 = oral cavity + cribiform plate (herpes labialis = cold sore)
        --> HSV2 = genitals (herpes genitalis)
        
        HSV1 / HSV2 = "ONE BRAIN, 2 MENINGES"
        --> HSV1 = encephalitis
        --> HSV2 = meningitis
        
        HSV1 = most common cause of sporadic encephalitis
        
        HSV1 gives you 2 TEMPORARY things:
        --> " TEMPORARY LABLIAS and TEMPORAL LOBE enchepalitis
        --> Herpes labialis
        --> HSV1 most common cause of sporadic temporal enceph in young people
        
        Notes:
        
        HSV-1 usually affects the mouth, but can be spread to the genitals
        
        HSV1 / HSV2 = "FIRST you KISS, 2nd you FUCK"
        --> HSV1 = oral cavity + cribiform plate (herpes labialis = cold sore)
        --> HSV2 = genitals (herpes genitalis)
        
        Clinical Cases
        
        Clinical Case
        
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        HSV1 example
        
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        HSV-1 Complications
        and Sequelae
        
        HSV1 = most common cause of sporadic encephalitis
        
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        *HSV 2
        (Herpes Simplex Virus 2)
        
        HSV1 / HSV2 = "FIRST you KISS, 2nd you FUCK"
        --> HSV1 = oral cavity + cribiform plate (herpes labialis = cold sore)
        --> HSV2 = genitals (herpes genitalis)
        
        Notes:
        
        HSV-2 usually affects the genitals, but can be spread to the oral route
        
        *Tzank test for HSV
        
        "TZANK Heavens I don't have HERPES"
        
        Tzank smear of HSV-1 ulcers shows giant cells that are multinucleated
        
        HERPES HARP GATES of DS DNA
        
        HSV1 HERPES HARP GATE sit on top of a TEMPORAL ENCEPHALITIS
        --> HSV1 most common cause of PSORADIC ENCEPHALITIS
        
        HSV2 HERPES HARP GATE was built by MEN IN TIGHTS
        
        HERPES WEDDING with HERPES HARP and GENITAL GENTLEMAN bring their parents APPLE CYCLOPS and VEIL CYCLOPS when they ar walking down the aisle FAN CYCLOPS blows wind into HERPES HARPS hair
    - - *CMV = HHV5 (Cytomegalovirus)
        
        CYTO - MEGALO transplant
        --> "sighto" --> affects the eyes
        --> retinitis
        --> MEGAlow transplant = infects lung transplants
        
        Cyto is an opportunistic virus
        --> HIV, congenita
        
        most common in lung transplants
        --> post 3 monthss
        
        OWL EYE in CMV histology
        
        described as basonuclear cells with halos around them
        
        SIDE TOE VIRUS runs the TRAINS PLANTS DNA Railroad car carrying the special delivery of LETTERs and ENVELOPES filled with the NUDE pictures of JAN IN JAMAICA GANCYCLOVIR
        
        SIDETOE MEGALO TRAINS PLANTS is an eveloped DS DNA virus
        
        the TRAINS PLAINS has a HERPES HARP as a train whistle and OWLS EYE INCLUSION lights to make sure they know where they are going
        the OWLS EYE INCLUSION lights are not bright enough to see the DS DNA track
        they can't see anything at all
        
        so SIDE TOE driving the TRAINS PLANTS puts his BABY on the front of the TRAINS PLANTS and gives hima TORCHES to hold to light the DNA TRACK
        
        but he still can't see...
        
        just then the SIDE TOW driving the TRAINS PLANTS gets distracted by a NUDE MONA picture of JAN in JAMICA JANCYCLOVIR and runs over a BAND AID and RED EYES on a SARCOPHAGUS ESOPHAGUS and
        
        Gancyclovir = 1st line tx for SIDE TOE TRAIN PLAINS
        
        Tx of CMV
        
        1st line = GANCYCLOVIR
        --> special delivery by the SIDE TOE driving the TRAINS PLANTS on DNA TRACK carrying ENVELOPES filled with
        
        NUDE PICS of JAN IN JAMIACA GANCYCLOVIR
        
        SIDE TOE CHANDELIER MTV CRIBS in the UTERUS with the TORCHES on the WALLS and the PARIED VENT CALFICATION COW pouring milk onto all the DESSERTS
        the HEADPHONES are so big and LOUD tha they shrink the BABYS head
        
        EARPHONES = deafness
        
        holoprosencephaly
        
        DESSERTS on the luxurious table at SIDE TOEs CHANDELIER MTV CRIBS uterus
        
        PAIRED VENT CALCIUM COW
        --> SIDE TOE CHANDELIER TORCHES = periventricular calcifications
        
        blueberry muffin RASH
        --> SIDE TOE CHANDELIER TORCHES = blueberry muffin RASH
        
        TIKI MASK RASH
        --> SIDE TOE CHANDELIER TORCHES = petechial rash
        
        OREO on RED TIN
        --> SIDE TOE CHANDELIER TORCHES = chorioretinitis
        
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        *Mononucleosis in EBV vs CMV
        
        EBV mono is Monospot +
        
        CMV mono is Monospot -
        
        Monospot test tests whether the virus agglutinates horse erythrocyte or not
        
        Clinical Cases
        
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        *Kaposi Sarcoma HHV 8 Viruse
        
        HHV 8 = Adult Kaposi Sarcoma Herpes
        --> Kaposi sarcoma = neoplasm of endothelial cells
        
        *ROSEOLAS Infant HHV 6/7 Viruse
        
        HHV 6/7 = Infant ROSEOLA Herpes Virus
        --> ("ROSEOLA = fever first, ROSY cheeks LATER")
        
        ROSELOA ROSY O OLYMPICS for BABIES where they try to swing through the big ROSY O
        
        ROSEOLA ROSE O virus = seen in babies
        
        ROSEOLA ROSE O ring sits on top of the DS DNA columns
        
        the BABY beats the FEVER BEAVER by using her cheat sheets in her ENVELOPE and counterbalancing himself by hanging a HERPES HARP with a 6 SAXAPHONE on it
        
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