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Jaundice (Congugated (Uncongugated (Fat Soluble
Can cross BBB
not in…
Jaundice
Congugated
Uncongugated
Fat Soluble
- Can cross BBB
- not in Urine
- Urine normal color
- Peds: Kernicterus (not poss in adults)
H2O soluble :ocean:
- can't cross BBB
- stuck in urine when excreted
- Darkens Urine
Bilirubin system
Prehepatic
Intrahepatic
-
- Dubin Johnson (CB)
- Rotor (CB) Black liver
- Hepatitis/Cirrhosis (mixed)
- viral hepatitis (CB #1 cause)(Pretest FM)
Complicated labs
- Crigler Najjar (UB)
- Gilbert (UB)
-
Hemolysis
Free Hbg
Uncongugated Bilirubin (UB)
- means by which bilirubin is transported to liver
2,3 UDP Glucylronyl Transferase (rate limit)
- overloaded in prehepatic jaundice
Congugated Bilirubin
- eliminated in stool :poop:
Jaundice:
- painful = gallstones
- painless = ca :crab: or stricture :snake:
- PSC
- PBC (intrahepatic jaundice)
Jaundice:
- hemolysis :explode:
- resorption of hematoma
- What you see w/ elevated bilirubin, just by knowing what kind of bilirubin it is
- Discussion of Jaundice: Yellowing of the skin and eyes, sublingual mucosa then skin then eyes :eyes: