RAAS
Renin
AT1 increases
AT2 emerges from lung vasculature
Via ACE
Cleaves angiotensinogen: floating around waiting for renin
Effects
Constrictor
Increases GFR
Increases SNS
Increased reabsorption of NaCl at CT
Increases aldosterone release
Direct fluid regulation
Indirect fluid regulation
ACE inhibitors
Decreased Aldosterone
Decreased GFR
Dilation: decreased TPR
Increased renin
Increased AT2
Decreased preload
Decreased afterload
Decreased Na+ and H2O retention
Decreased AT2
Decreased bradykinin
Renin inhibitors
Beta blockers
Decreased renin, AT1. AT2, and Aldosterone
Decreased renin plasma activity
Decreased BP
Increased renin release
Spironolactone
Aldosterone receptor blocker
Decreased BP
Increased RAAS axis
Decreased conversion of angiotensinogen to AT1
JG cells @ Afferent
Sympathetics
Low blood volume
Increased Na+ and BP
Angiotensinogen --> AT1
with ACE @ lungs
Angiotensin 2
Increases the release of endothelin-1
Macula densa monitor: tells JG cells
Modified smooth muscle cells
Beta 1
With constant decrease in blood flow: JG hyperplasia from constant stimulation
Baroreceptor response