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RAAS (JG cells @ Afferent (Sympathetics (Beta 1), Modified smooth muscle…
RAAS
JG cells @ Afferent
Sympathetics
Beta 1
Low blood volume
Increased Na+ and BP
Macula densa monitor: tells JG cells
Modified smooth muscle cells
Baroreceptor response
With constant decrease in blood flow: JG hyperplasia from constant stimulation
Renin
AT1 increases
AT2 emerges from lung vasculature
Via ACE
ACE inhibitors
Decreased Aldosterone
Decreased GFR
Dilation: decreased TPR
Decreased afterload
Increased renin
Increased AT2
Decreased preload
Decreased Na+ and H2O retention
Decreased AT2
Decreased bradykinin
Effects
Constrictor
Increases GFR
Increases SNS
Increased reabsorption of NaCl at CT
Direct fluid regulation
Increases aldosterone release
Indirect fluid regulation
Increases the release of endothelin-1
Cleaves angiotensinogen: floating around waiting for renin
Angiotensinogen --> AT1
with ACE @ lungs
Angiotensin 2
Renin inhibitors
Decreased renin plasma activity
Decreased BP
Increased renin release
Decreased conversion of angiotensinogen to AT1
Beta blockers
Decreased renin, AT1. AT2, and Aldosterone
Spironolactone
Aldosterone receptor blocker
Decreased BP
Increased RAAS axis