RAAS

Renin

AT1 increases

AT2 emerges from lung vasculature

Via ACE

Cleaves angiotensinogen: floating around waiting for renin

Effects

Constrictor

Increases GFR

Increases SNS

Increased reabsorption of NaCl at CT

Increases aldosterone release

Direct fluid regulation

Indirect fluid regulation

ACE inhibitors

Decreased Aldosterone

Decreased GFR

Dilation: decreased TPR

Increased renin

Increased AT2

Decreased preload

Decreased afterload

Decreased Na+ and H2O retention

Decreased AT2

Decreased bradykinin

Renin inhibitors

Beta blockers

Decreased renin, AT1. AT2, and Aldosterone

Decreased renin plasma activity

Decreased BP

Increased renin release

Spironolactone

Aldosterone receptor blocker

Decreased BP

Increased RAAS axis

Decreased conversion of angiotensinogen to AT1

JG cells @ Afferent

Sympathetics

Low blood volume

Increased Na+ and BP

Angiotensinogen --> AT1

with ACE @ lungs

Angiotensin 2

Increases the release of endothelin-1

Macula densa monitor: tells JG cells

Modified smooth muscle cells

Beta 1

With constant decrease in blood flow: JG hyperplasia from constant stimulation

Baroreceptor response