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Immunology - Cytokines (5 Types of Cytokines Interleukins TNFs = Tumor…

- - - - IL - 10
        
        anti-inflammatory
        
        usually goes with IL-8, a strong chemotaxin to go against its effects
        
        IL - 8
        
        strong chemotaxing for neutrophils and
        
        Clinical Cases
        
        IL-8 (from macrophages) and Neutrol chemotaxis for inflammation
        
        4 more items...
        
        Clinical Case
        
        2 more items...
        
        IL-2
        
        Notes:
        
        note that IL-2 is released exclusively by ONLY T-cell lymphocytes
        
        T = 2 --> IL-2 --> think "secondary T cell reaction"
        
        IL-2 is released from T cells after they have been activated by an antigen
        
        IL-2 is mainly for B cells proliferations
        
        but also important is the T cell proliferation and also Macrophages/NK cells
        --> this is what is useful in cancer treatment with IL-2
        
        HOT T Bone stEAK
        
        1 = HOT =
        --> IL 1 --> fever
        
        2 = T = IL 2 --> T cell proliferation
        
        3 = Bone = IL 3 --> B cell proliferation
        
        4 = stEAk = IL 4 --> IgE (class witch from IgG)
        
        5 = stEAk = IL 5 --> IgA / Eosinophil recruitment
        --> atopy and allergic reactions
        
        6 = stEAK = IL 6 --> aKKute phase prtoein production
        --> atopy and allergic reactions
    - - Notes:
        -
        
        *Interferon Alpha and Beta
        
        made in ALL cells as a protection system against Double stranded RNA viruses ONLY
        
        released by human cells infected with a DS RNA virus
        
        very smart since the enzymes they release that degrade RNA are ONLY activate if there is DS RNA present in the cell
        
        INF - Gamma
  - - - Notes:
        
        note that IL 4 and IL10 are both anti inflammatory
        
        thus Th2 cells are some kind of regulator on the T cell activation
        
        where TH1 cells are self proliferative for both activating themselves and B cells
    - - CD 40 Class Switching of B cells
        
        B cells have CD 40 used for class switching
        
        CD40L on T h cells activates the B cell to class switch to a different antibody
        
        CD40 = "4D = 4 Different classes"
        
        think of B cells as NAIVE and STUPID
        
        Th cell once binds CD40L to CD40 for class switch
        
        TCR and CD4 of Th cell send cytokines to the B cell to tell it what kind of antibodies to make
    - - Clinical Cases
        
        Clinical Case
        
        Clinical Case
        
        Notes:
        
        note that