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Chronic Asthma (Symptoms (dyspnea, cough, Expiratory wheezing, Chest…
Chronic Asthma
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Diagnosis
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Recurrent episodes of wheezing, dyspnea, or cough
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Pathophysiology
Exposure to antigen
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Cross-linking of IgE and the antigen causes degranulation of mast celss releasing inflammatory mediators histamine, bradykinins, leuktrienes, prostaglandins, platelet-activating factor, and interleukins
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The inflammatory mediators cause vasodilation, increased capillary permeability, mucosal edema, smooth muscle contraction, and mucous secretion
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