Please enable JavaScript.

Coggle requires JavaScript to display documents.

Local anesthetics (routes of administration (epidural injections (compared…

- - - - decreased platelet aggregation
      - decrease overall stress response
    - - beneficial in major aortic surgery
- - - - fatigue and dizziness
  - - - tinnitus, agitation, restlessness, tongue numbness, metallic taste
- - - - dosage, site injection, drug tissue binding, local blood flow, use of vasoconstrictors, chemical physicochemical properties of the drug
  - - - sequestration in lipophilic storage area
      - first rapid distribution into highly perfused organs (brain, liver heart, kidney)
        
        then slower distribution into moderately perfused tissue (muscle , GI tract)
  - - - hydrolysis via CYP 450 system
      - toxicity more likely with hepatic disease
      - decreased hepatic elimination in reduced hepatic blood flow
- - - - procaine
    - - lidocaine
    - - bupivacaine
    - - most widely used for dental procedures
  - - - short term pain relief in musculoskeletal and joint pain
      - pain refilef durig wound debridement
      - long term pain relief in cancer
      - treatment of chronic pain
        
        lidocaine patch
- - - - otitis exerna,sore throat, toothache, teething,sunburn relief,canker sores, cold sores
  - - - tesslon perles