Please enable JavaScript.
Coggle requires JavaScript to display documents.
Viruses - Hepatitis Viruses (dropped image link (*HBV blood, baby making…
Viruses - Hepatitis Viruses
*Home
*HBV
blood, baby making, birthing
lees common than HCV = very common
HBV Life Cycle and Serum Markers
First you get the surface antigen, then the envelope
anti HBsAg IgG
you don't get until the virus is GONE!
--> either by vaccine or having fought the virus
--> you retain the
anti HBsAg IgG
for life
HBV *Serum Markers
First you get the surface antigen, then the envelope
anti HBsAg IgG
you don't get until the virus is GONE!
--> either by vaccine or having fought the virus
--> you retain the
anti HBsAg IgG
for life
Clinical Cases
Clinical Case
3 more items...
Clinical Case
3 more items...
Chronic HBV Infection
HBsAg > 6 months
Acute HBV Infection
high IgM = IgG and HBsAg < 6 months
HBV *Life Cycle
HBV has a reverse transcriptase that COMES with it
--> same as HIV
--> except HBV does NOT NEED to integrate into the host like HIV REQUIRES to survive
--> HBV cans kip that step and just move on
note that HBV is enveloped so will not lyse the cell
Clinical Cases
Clinical Case
Clinical Case
Notes
:
note that
Clinical Case
Notes
:
note that
Clinical Case
HBV and HCC worldwide
HBV largest cause of HCC in developing countries
HBV passed on by 3 Bs
--> blood, baby making, birth
vaccination against HBV stops birth HBV and lowers HCC
*Transmission of HBV
HBV is passed on by the Bs
--> birth, blood, baby making
in developed countries most = 70% are caused by sexual transmission
Acute HBV Presentation
note that HBV can classically present as a serum like vasculitide sickness (fever,fatigue, urticaria rash) on top of a regular hepatitis P/C (high ALT,AST, RUQ pain, etc.)
Clinical Cases
Clinical Case
Clinical Case
Notes
:
note that
HBV Arteritis = PAN
PAN = polyarteritis Nodosa
hePANitis B
HAPPY TIE BEE rides around the DS ROUND DNA REVERSE TRAIN TRACK with at its centre the 3 MONTH INCUBATION TREE
3 month incubation period
double stranded dna
the WHOLE GOAL of the HAPPY TIE BEE on the ROUND HEP B TRACK is to spread his LIVER VIRUS, but it is difficult since this is a REVERSE TRAIN TRACK
reverse transcriptase in HAPPY TIE BEE
since it is a REVERSE DNA TRAIN TRACK, HAPPTY TIE BEE secures 3 separate ENVELOPE CARTS to make sure his LIVER VIRUS gets SPREAD and he fills EACH ENVELOPE with a type of BEE
ENVELOPE 1 HAPPY TIE BEE = BABY making MOM AND DADDY BEEs
--> transfer in BABY MAKING
ENVELOPE 2 HAPPY TIE BEE = BABY and m
other
--> transfer at BIRTH
ENVELOPE 3 HAPPY TIE BEE = BLOOD
--> transfer through BLOOD
CHRONIC GRANNY has her PET HAPPY TIE BEE in ONE HAND and her BABY in the other and is trying to figure out which one she will sell to BUY some ROSE CIRROSIS LIVER fromt he MAN BRAN PRO LIFTER who is selling them on the STREET
she has her BUDGET set out already where she spends 10% on her PET HAPPY TIE BEE and the other 90% on her BABY
so it is an EASY CHOICE to get rid of her baby to buy some CIRROSIS RED ROSES from the MAN BRA PRO LIFTER
meanwhile ... the POLLY ARTIST captures the terrible seen in her painting where the OLD CRONE sells her baby to the MAN BRA PRO LIFTER to buy some CIRROSIS RED ROSES on the street and the 2 of them get killed in the scene by the LIVER CARS IN GNOME
POLLY ARTIST in CHRONIC CRONE with PETHAPPY TIE BEE
*HCV
Hep C =
COMMON, Cytotoxic COUNCILMAN BODIES
--> most common of the Heps
--> councilman bodies are eosin staining dead hepatocytes from cytotoxic induced apoptosis for hepatocytes infected with HCV
very common since has many mutations of its glycoprotein for its envelope
--> NO proof reading for its RNA POL 3
--> reads 3 - 5
--> makes 5 --> 3, but NO backwards proofreading like ours
--> ACTUALLY an ADVANTAGE for it to mutate
due to IV drug use and Blood transfusions
--> usually undiagnosed and leads to chronic infection
--> leads to cirrhosis and HCC
HCV Treatment
3 targets for HCV
RNA dependent RNA POL blockers
-->
sofosbuvir
HCV protease blockers
--> host rRNA makes the Hep C proteins as one big protein
the HEP C protease then cleaves it into functioning proteins
-->
simeprevir
proteins for viral replication and assembly
ledipasvir
HCV - Cytotoxic COUNCILMAN BODIES
Hep C =
COMMON, Cytotoxic COUNCILMAN BODIES
--> most common of the Heps
--> councilman bodies are eosin staining dead hepatocytes from cytotoxic induced apoptosis for hepatocytes infected with HCV
HAPPY TIE LIVER CAT leaves the ICE CATHEDRAL CHURCH (that still keeps its + sign on for him to return) to live on the WRONG SIDE of the TRAINS PLANTS TRACKS where he becomes a COMMON low level DRUG DEALER
COMMON low level DRUG DEALER
--> COMMON and COUNCILMAN bodies in LIVER
TRAINS PLANTS TRACKS = HAPPY TIE LIVER CAT is #1 cause of liver transplants
HAPPY TIE LIVER CAT is just a low level COMMON drug dealer, he answer to the head boss = FLAVA FLAVE drug dealer and hands out FLAVA FLAVES drug ENVELOPES
Enveloped virus
FLAVA FLAVE VIRUS
a CHRONIC old granny has spent nearly 70% of her EARNINGS to become a CHRONIC HAPPY TIE LIVER CAT for LIFE
70% of cases of HAPPY TIE LIVER CAT disease go to chronic
accross the tracks the RIVAL drug gang goes in for a DRIVE BY in their LIVER GNOME IN CAR
they shoot at the outside body guard = MAN BRA PRO LIFTER
--> membranous proliferative GN
*Virulence for HCV
the reason why our bodies cant kill off HCV is that its viral envelope keeps mutating so quickly
this is since its DNA POL doesn't have the backward proofreading
--> which actually ends up helping the virus
for humans missing proof reading is a bad thing, but for viruses, missing proofreading is a good thing for thier survival
*HDV
Hep D =
DEPENDENT
on borrowing a
COAT
for Hep B
HDV can't infect hepatocytes unless it has HBV coat
common in chronic HBV drug users, etc who hav active HBV all the time
*HAV
most common viral hepatitis of young people
usually self limiting
causes BALLOON SWELLING necrosis of hepatocytes
then leads to cytotoxic apoptosis = COUNCILMAN bodies
Balloon swelling apoptosis of hepatocytes in HAV
HAPPY TIE GUY travels to a FOREIGN APPLE STAND in INDIA that is right next to a DAYCARE CENTRE
HAPPY TIE GUY APPLE STAND = HEP A
can infect daycare centres toys from FECAL ORAL ROUTE
the OWNER of the HAPPY APPLE and PICKLE CORN STAND is a FEVER BEAVER and he serves the HAPPY APPLE STAND APPLEs with a 4 FORK
4 FORK incubation period for HAPPY APPLE STAND APPLES virus
throwing up on all the apples and the YELLOW JAUNDICE JANITORs job is to just continuously mop up the puke off the HAPPY APPLE and PICKLED CORN STAND APPLES
emesis
jaundice
*Family subtypes
HAV
= picoRNA virus
--> affects healthy young people and common, but not vaccinated for usually (=pre MnOP RNA virus)
--> part of picoRNA PERCH
-->
PERCH
= Hepadnavirus = HAV
HBV
= circular/enveloped
--> part of
HHAPPPY
DNA viruses
HCV
= part of flaviviruses yellow fever
--> + sense RNA
--> part of
HHAPPPY
DNA viruses
HEV
= Naked virus
--> part of
"PAPP smears and CPR to naked HIPpies"
-->
HIPpies
= HEpesvirus naked
Hepatitis *Vaccinations
surface, core and envelope antigens
