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ANTI-ARRYTHMICS (Class 1 (1A (Open Na+ channel (Phase 0 (Decreased rate of…

- - - - Phase 0
        
        Decreased rate of rise/slope/upstroke
    - - Affects length of the refractory period
    - - Prom Queen and Prom King
        
        Binding affinity: intermediate
        
        K+ channel blocker: longer depolarization
        
        Prolonged effective refractory period
        
        WWP syndrome: type of SVT
        
        Lupus, Cinchonism, Torsades
        
        Prolong QT: because AP prolonged
  - - - Binding affinity: low
        
        Little effect on phase 0, shorter AP duration
        
        Ventricular arrythmias, infarcted myocardium
        
        Neurological side effects
  - - - Dramatic effect on QRS
        
        No effect on AP duration, no effect on K+
        
        A-fib