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Pharmacology - antivirals (dropped image link (*Zanimivir and Oseltamivir …

- - - - Clinical Cases
        
        Clinical Case
        
        Clinical Case
        
        Notes:
        
        note that
      - ZENA and OSELOT OSELTAMIVIR MOVING VAN hep out FLUTE VIRUS A and B move into their new home
        
        ZENA MOVING MOVING VAN
        
        OSELOT MOVING VAN OSELTAMIVIR
        
        FLUTE VIRUSA and B
        
        when FLUTE VIRUS A and B open up their boxes all they find are TREATMENT BOTTLES and PURPLE AXES in it
        
        ZENA OSELOT MOVING VAN are for tx and PURPLE AXES
        
        when ZENA OSELOT MOVING VAN leave they always trick their victims and steak from them, they CHAIN UP THE EXIT and CHAIN up the NEURAMINIDASE birds in FLUTE BOXES from FLYING OUT and catching them
        
        ZEN OSELOT MOVING VAN CHAIN up NEURIMINDASE birds from flying away
        
        ZENA OSELOT MOVING VAN
  - - - APPLE CYCLOPS in the GARDEN of EDEN with his TEMPTER = IGUANA LOG who hands EVE the SIMPLE HERPES HARP girl and ADAM = VARSITY ZORRO their apples to eat
        
        APPLE CYCLOPS and GUANOSINE IGUANA LOG
        
        EVE = SIMPLE HERPES HARP VIRUS
        
        ADAM = VARSITY ZORRO VIRUS
        
        APPLE CYCLOPS first STEALS EVE HERPES HARP VIRUS THIGH HIGH KITE KINASE from her
        
        THYMINE KITE KINASE activates APPLY CYCLOPS
        
        APPLE CYCLOPS stealling EVE HERPES HARPS THIGH HIGH KITE KINASE is what gives her nothing to do eventually makes her EAT the forbidden CYCLOPS APPLE
        
        the APPLY CYCLOPS drops an APPLE on EVES head and give her a HEAD ACHE and then her GI comes out of the TREE to say DONT EAT THE CYCLOPS APPLE
        
        APPLE CYCLOPS HEADACHES
        
        APPLE CYCLOPS GI UPSET that EVE is eating the APPLE CYCLOPS
        
        ADAM = VARSITY ZORRO VIRUS gets caught in the CNS WEEDS that grab him
      - Acyclovir works for Herpes HHV 1-3
        
        not for HHV 4,5
  - - - GANDOLF the CLOVER STAFF fights the SIDE TOE MONSTER BALROG on the DNA BRIDGE
        
        GANDOLF the CLOVER GANCLOVIR
        
        SIDE TOE MAGOLO VIRUS MONSTER
        
        when GALDOLF the CLOVER GANCYCLOVIR says YOU SHALL NOT PASS he makes a GUANA LOG climb onto the DNA BRIDGE and blocks it
        
        GANDOLF the CLOVER GUANO LOG cuts DNA BRIDGE
        
        then as the SIDE TOE MONSTER is falling down he also WHIPS GANDOLF CLOVER with his POLY MIRROR CHAIN and brings him down with him
        
        GANDOLF COLVER with SIDE TOE VIRUS MONSTER has BOTH GUANO LOG DNA BRIDGE
        
        PLUS it has POLLY WITH MIRROW CHAIN that whips GANDOLF CLOVER
  - - - ROBBA VIRIN VIRUS steals from INSYNC with MONOPHOSPHATE MONKEY and cause a mutation in INSYNCs RNA RHINO that pulls INSYNCs SUPER RV van on their INSYNC WORLD TOUR
        
        ROBBA VIRUS = Ribavirin
        
        INSYNC MONOPHOSPHATE MONKEY inhibitor
        
        RNA RHINO MUTATES
        --> ROBBA VIRIN VIRUScauses RNA RHINO MUTATIONS
        
        when INSYNCS with MONKEY PHOSPHATE RNA RHINO MUTATES he goes on a rampage with the INSYNC WORLD TOUR SUPER RV
        
        ROBBA VIRIN VIRUS INSYNC RNA RHINO SUPER RV
        --> RUPER RV VIRUS = ROBA VIRIN VIRUS
        
        the SUPER RV van runs over a HAPPY TIE LIVER CAT and also a TERTAOGEN TARANTULA after its RNA RHINO MUTATION from ROBBA VIRIN VIRUS
        
        ROBBA VIRIN VIRUS = HAPPY TIE LIVER CAT
        
        ROBBA VIRIN VIRUS = TERATOGENIC TARANTULA
  - - - FOX CAR NET is racing against SIDE TOE REDTIN EYES to win the affection of HERPES HARP that is RESISTANT TO APPLE CYCLOPS trying to pick her up for years
        
        FOX CAR NET = foscarnet
        
        FOX CAR NET is used for both SIDE TOE VIRUS RED TIN EYES
        
        also used for HERPES HAPR that is RESISTANT to APPLE CYCLOPS
        
        FOX CAR NET has SUPED UP mirrors = POLLY WITH CHAIN MIRROR and he also has a P ON A LOG PIT CREW that help him win the race against SIDE TOE RED TIN EYES
        
        FOX CAR NET = POLLY MIRROR
        
        FOX CAR NET P ON A LOG PIT CREW = P analog for DNA synthesis POLLY MIRROR
  - - - *Nucleotide analogues
        
        Cidofovir ("CITY GAN is hotter")
        
        2nd generation antivirals
        --> ONLY require the HOST cell kinase to phosphorylate it to a TRI phosphate = 3P = active form of the drug
        --> thus good for resistant HSV and other viruses CMV
        
        *Cidofovir
        -
        
        CIDOFOVIR = SIDE SHOW FIRE sets fire to all the REJECTS of the FAIR = APPLE CYCLOPS RESISTANT EVE HERPES HARP and the SIDE SHOE SIDE TOE VIRUS, the SIDE SHOW FIRE was all started by teh POLYMERASE POLY trying to break free from her CHAINS by inhibiting them
        
        SIDE SHOE FIRE = CIDOFOVIR
        
        SIDE SHOE SIDE TOE VIRUS
        
        resistant APPLE CYCLOPS
        
        resistant POLLY MIRROR IN CHAINS POLYMERASE
        
        Clinical Cases
        
        Clinical Case
        
        Clinical Case
        
        Notes:
        
        note that
      - *Nucleoside analogues
        
        acycolvir, gancyclover + others
        
        first generation antivirals
        --> require FIRST the viral kinase to phosphorylate it to a monophosphate = 1P = nuclo TIDE
        --> require SECOND the host cell kinase to phosphorylate it to a TRI phosphate = 3P = active form of the drug
        
        *Acyclovir
        -
        
        *Gancyclovir
        -