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Thyroid Nodules (Cancers (Papillary (Most common (85%)
orphan Annie…
Thyroid Nodules
Cancers
Papillary
Most common (85%)
- orphan Annie nuclei
- Tx: resection
-
Follicular
"The one you want to have"
- Looks like real thyroid
- hematogenous spread, early mets
- Great response to RAI
-
Medullary
Calcitonin
- MEN2A/B
- RET oncogene
- Pheochromocytomas
Anaplastic
"The one you DONT want to have"
- elderly pt :older_man::skin-tone-3:
- invasive
- kills quickly
Risk factors
Pt
Physical
U/S findings
- Solid mass
- Hypoechogenic
- (difference from thyroid tiss)
- Size difference > 2cm
- micro calcifications :glass_of_milk:
- irregular borders
Fixed firm hard nodule
w/ nearby LAD.
:pencil2: most malignancies are painless, but don't rely on this finding for cancer.
- previous Radiation :radioactive_sign: :radioactive_sign:to head/neck
- personal hx, famHx of cancer :crab:
- hoarseness :horse:
- <20 yo :girl::skin-tone-4:
- >60 yo :older_man::skin-tone-4:
Nodule found
TSH
:green_cross: Low TSH
Low risk nodule
-
RAIU scan
:check: Hot
- hyper functioning nodule
- lowest risk for cancer (no biopsy)
- Tx for hyperthyroidism (RAI, ablation)
:green_cross:Cold Nodule
- Nonfunctioning
- :warning:risk for cancer!
-
:check: normal, elevated TSH
-
:pencil2:Brian's note: Cold, Large, Scary? FNA