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Fructose-2,6-Biphosphate (Inhibited by (Fructose-1,6-Biphosphate,…
Fructose-2,6-Biphosphate
Inhibits Gluconeogenesis
Glucagon
Increased cAMP
Ac 2nd messenger
Gs
PKA
Phosphorylates
Fasting state
Stimulates Glycolysis
Insulin
Increased cAMP
Intrinsic tyrosine kinase activity
Auto-phosphorylation
PI3K path
Glycogen synthesis
Activation of protein phosphatase
MAP/RAS kinase path
Mitogen
Fed state
Stimulated by
PFK-1
Inhibited by
Fructose-1,6-Biphosphate
Gluconeogenesis
Conversion of alanine to glucose