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*Physiology - Equations (Cardiac (Blood Flow Equations
Flow = Q = P2 -…
*Physiology - Equations
Cardiac
Blood Flow Equations
- Flow = Q = P2 - P1 / R
- R = nL / r^4
--> note that resistance is to power of FOUR
--> "FOUR" = "Resistance"
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CO = Cardiac Output
- CO = HR x SV
- CO = rate of O2 consumption / (artery O2 - vein O2)
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*drug equations
- Loading and Maintenance Doses and Half Life
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half life
- time reuired for drug concentration to become 50%
- just keep dividing by 2
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*Steady state of drugs
- takes 4 to 5 half lives
--> note this is for 1st order kinetics with constant infusion of the drug by IV
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*Calories
- 4 ,7 ,9
--> carbs/protein
--> ethanol
--> fat
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*Bioavailability = F
- bioavailability = F since it is a fraction
--> Bioavialability is ALWAYS the fraction from a route other than IV divided by IV
--> AUC of other route / AUC of IV drug
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*renal
- FF = GFR/RPF
- RPF = RBF x (% of plasma volume)
- RPF = RBF x (1 - hematocrit)
--> think plasma = RPF is a fraction of blood = RBF
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from Inulin Creatinin and PAH
- creatinine gives GFR
- PAH gives RPF
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*Net renal excretion
- Excretion = Total filtration - Net Secretion/Absorption
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*Resistance in Cardiac blood vessels
- PARALLEL resistance
--> inverse total resistance = SUM of all INDIVIDUAL inverse resistance
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