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Pharmacology - Antifungals (dropped image link (dropped image link…
Pharmacology - Antifungals
*Azoles
"Azooles = AK+ 47s, metal AMMO, and NIGHT vision blow holes in the Fungi with Mg++ and K+ bullets "
-->
"AK+ 47"
= Azoles / 450 enzyme inhibition
-->
"metal AMMO, and NIGHT vision"
= poke holes for K+ and Mg++ ions
-->
"CYP450 SICKFACES"
= KF = ketoconazole and fluconazole / ALL AZOLES are big CYP inhibitors
end in
azole
CYP 450
normally converts
lanosterol
to
ergosterol
for cell membrane
--> side effect of liver dysfunction
--> effects our liver P450 enzymes
Side Effects
MOA = inhibit the P450 enzyme
--> normally converts lanosterol to ergosterol for cell membrane
--> side effect of liver dysfunction
--> effects our liver P450 enzymes
testosterone inhibition
--> leads to gynecomastea due to testosterone shunting to estrogen
--> ketoconazole high risk of gynecomastia
-->
**ketocon is a CUTIE with his new BOOBS
Pyrimidine analogue = Flucytosine
"FLU the CYTE of DNA synthesis"
prodrug converted to 5-Flurouracil
interferes with fungal RNA and protein synthesis
Cell membrane = Polyenes
target ergosterol in the cell wall
poke holes in cell wall
allow leakage of K+ ions and Mg+
--> think my favourite things in USMLE mornings
--> I was taking Nystatin for candidiasis
--> Mg++ water drink, coffee bananas
-->
MUST supplement K+ and Mg+ with Polyenes
IV systemic =
Amphotericin B
topical / oral candidiasis =
Nystatin
"Azoes = AK+ 47s, metal AMMO, and NIGHT vision blow holes in the Fungi with Mg++ and K+ bullets "
-->
"AK+ 47"
= Azoles / 450 enzyme inhibition
-->
"metal AMMO, and NIGHT vision"
= poke holes for K+ and Mg++ ions
*Amphotericin B
used by IV, poor oral bioavailability
tx for cryptococcus neoformins
Side effects of Amphotericin
Nephrotoxicity
number 1 side effect for Amphotericin B
--> Amphotericin TEARS holes in the kidney
--> this is where the K+ and Mg+ leakage happens
--> this then can cause the K+ loss effects =
2 more items...
*Nystatin
oral and vaginal candidiasis
swish and swallow for oral
too toxic to be taken IV
Echinocandins
ECHO what is UNIQUE to FUNGI = GLUCAN
--> glucan
end in fungin
--> since glucan is specific to FUNGI
Griseofulvin
"GREASY mitotic microtubules"
targets mitosis of fungi
--> think of GREASY mitosis fingers (microtubules) extending from the dipoles of the cell
Terbinafine
stops lanosterol synthesis
"a FINE SEXY LADY"
Terbinafine = lanosterol epoxidase inhibitor
*DIRTY USMLE