Please enable JavaScript.
Coggle requires JavaScript to display documents.
Opioid (Part 1) (Opiod receptors (Mu receptor : analgesia effect (opens up…
Opioid (Part 1)
Opiod receptors
mu receptor, the delta receptor, the kappa receptor, and the ORL-1 receptor.
-
-
Delta receptor
-
agonist binds to the delta receptor is induces a conformational change that causes the activation of a specific G-protein.
inhibits the membrane bound enzyme adenylate cyclase and prevents the synthesis of cAMP. The transmission of the pain signal requires cAMP to act as a secondary messenger, and so inhibition of this enzyme blocks the signal
-
Orphan receptor
-
biological effects such as memory processes, cardiovascular function, and renal function.
-
-
-
Morphine
-
depression of cough due to respiratory depression, nausea caused by increased vestibular sensitivity, and decreased gastric motility and some constipation.
-
-
-
-
Heroine
still legally prescribed terminal patients, as diamorphine.
-