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Innate Immune System (Pattern Recognition Receptors (CELL-ASSOCIATED (Toll…
Innate Immune System
Pattern Recognition Receptors
recognize molecular patterns: PAMPs und DAMPs --> overall structure not molecular detail
LOW DIVERSITY: 1 receptor for as much as possible AGs --> recognition of many AGs with 1 receptor
encoded in germline
IDENTICAL in each indidual
NON-CLONAl (same in all cells of a lineage)
tolerant against self (wegen evolution)
CELL-ASSOCIATED
in Plasmamembrane, Cytosol or Endosome
Toll-like Receptor (membrane)
signals to nucleus --> transcription of genes for IR and infalmmation
Cytokines, Chemokins, Costimulators, Adhesion Molecules
e.g. Interferon Type I --> antiviral state
Nod-like Receptor (cytosol)
formation of Inflammasome
--> activates Caspase
--> cleaves Pro into IL-1Beta (inflammatory cytokine)
SOLUBLE
activate the CS
Components:
Cells of innate IS
Complement System (innate humoral immunity) (MAC --> cell lysis)
Epithelial Barrier
a) physical barrier
b) makes antibiotics; + charge; interferes with bact. physiology
c) intraepithelial lymphocytes: receptors for microbial AG --> kill it
act immediately --> protection until adaptive IS kicks in
Inflammation
a) Local Inflammation
b) Systemic Protective Effect
c) Systemic Pathologic Effect
General Facts
is not the main carrier of imm. memory