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IBD (UC (Crohn's (Bimodal: 20's & 50's (Skip lesions:…

- - - - Skip lesions: entire GI tract
        
        Transmural
        
        Non-caseating Granulomas
        
        Watery diarrhea :sweat_drops:
        
        insidious onset
        
        multiple BM:poop::poop:/day
        
        nutritional deficiency
        
        weight loss
        
        no cancer :forbidden::crab:
        
        these are all intestinal
        
        fistulas
        
        Terminal Ileum involvement
        
        B12 and fat malabsorb
        
        (weight loss)
        
        duodenum involvement
        
        osteopenia
        
        IDA
        
        Reserved for complications (not curative)
        
        fistula repair
        
        abscess drain :volcano:
        
        1 more item...
  - - - Superficial w/ Crypt abscesses
        
        Bloody diarrhea :poop:
        
        acute onset
        
        inflammatory = CRC risk :warning::crab:
        
        colonoscopy screening
        
        (8yo-rest of life)
        
        PSC
        
        p-ANCA
        
        Colectomy is curative
- - - - Severe
        
        Crohns: TNF inhibitors: infliximab
        
        UC: Surgery
        
        TNF inhibitors optionally
        
        Flares :red_flag:
        
        Prednisone
        
        UC: more bloody diarrhea
        Crohns: more watery diarrhea :sweat_drops:/weight loss
        
        Dx: r/o infection
        
        C Diff screen
        
        Perianal Disease?
        Tx: Drain
        
        Abx:
        Gram - (Cipro) :sunflower:
        Anaerobes - (metronidazole) :bullettrain_side:
      - Immune modulators: both UC/Crohns
        
        6-mercaptopurine
        
        Azathioprine
        
        unlikely: MTX
        
        :pencil2:Prednisone is an option: Hematuria side effect
    - - :pencil2:Superficial anti-inflammatory compounds, breaks apart and spreads
        
        better for UC
      - Mesalamine
- - - - risk of malignancy
        
        extra intestinal manifestations
        
        Surgery