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Reproduction (*Infertility causes in Women
PID = most common
-->…
Reproduction
*Infertility causes in Women
- PID = most common
--> history of PID can casue infertility due to the damage caused to para uterine structure (fallopian tubes etc.)
- endometriosis
--> can cause fertility
--> but it is reversible if you remove the endometriosis growths and cysts that form
*endometriosis
- can cause fertility
--> but it is reversible if you remove the endometriosis growths and cysts that form
Endometriosis NOTES
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Treatment
Secondary Surgical Treatment
- if Conservative treatment fails, move to laproscopic treatment
- laproscopy performed
--> both diagnostic and treatment
--> gives absolute diagnosis of endometriosis
--> endometriosis implants can be excised
Conservative Treatment
- NSAIDs to relieve abdominal and pelvic pain
- hormonal contraceptives used to lower the output and stimulation of the endometriosis implants
Clinical presentation
- typically have shorter menstrual cycles (< 28 days), longer days of menstrual flow, younger age of menarche
- after menstrual cycles have been established, usually develop dysmenorrhea
- severe pelvic pain
- endometriosis can cause infertility
*POI = Primary Ovarian insufficiency
- menopause by age < 40
- due to depletion of follicle pool
--> either didn't make enough follicles and retain them at puberty
--> normally make 2 million and have 25% of this left at puberty
--> or you lost them due to chemotherapy, etc.
- note that each month you are using up 20 follicles and only 1 is chosen
--> the remaining 19 that were not chosen undergo APOPTOSIS and die
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*Oogenesis, Follicles and Ovulation
Primary / Secondary OOcytes / Meiosis 1 and 2 Arresting stages
- meiosis arrest #1 - begins at puberty
--> PUBERTY = prophase of Meiosis 1
- meiosis arrest #2 - begins at ovulation and fertilization
--> ends at fertilization
--> fertilization needs a MALE = metaphase of Meiosis 1
Primary / Secondary OOcytes / Meiosis 1 and 2 Arresting stages CASE 1
- arrest #1 - begins at puberty
- arrest #2 - begins at ovulation
--> ends after fertilization
Notes:
- note that oocyte primary and secondary and meiosis is all happenning to the oocytes
- these are within the follicles that contain the oocytes and feed them
- thus the FSH growth of follicle and LH surge are happenning continuously each month while the oocytes are arrested in Meiosis prophase 1 = puberty state
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Notes:
- Gestation = mitosis of oogonium
- Birth = start making Primary OOcytes from the oogonium
- Childhood to puberty = Meiosis 1 prophase
--> think PUBERTY = PROPHASE 1
- MONTHLY MENSTRUATION = meiosis 1 complete / METAPHASE 2 arrest
- Metaphase 2 arrest = until MEN arrive
--> once sperm fertilize the metaphase 2 and entire meiosis 2 completes
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*Gynecomastea
- Gynecomastea = MALE KNOCKERS
--> "SOME Hormones Create KNOCKERS"
- spironolactone
--> both spironolactone and cimetidine both accidently block DHT recetors
- hormones
--> anything that causes low THD and high estrogen
- cimetidine
--> both spironolactone and cimetidine both accidently block DHT recetors
- Ketoconazole
--> antifungal AK47 CYP 450 inhibitor
--> blocks synthesis of ergosterol in fungi
--> blocks hormone steroids in humans, BUT blocks androgens more than ergosterols
--> lowers the androgen/estradiol ratio
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Reproduction terms:
- gravida = # times pregnant (regardless if brought to term)
--> primagravida = first pregnancy
--> nulligravida = NEVER been pregnant (null = means without)
- para / parity = # of pregnancies brought to term
--> nullipara = NEVER brought a fetus to full term (null = means without)
- an / oligo / poly hydramnios = amount of amniotic fluid in amniotic sac
- colpo- / colpos- = referring to the vagina
- hematocolpos = collection of blood in the vagina
- mucocolpos = collection of mucus in the vagina
- salpingo- = referring to the fallopian tubes (also Eustacian /auditory tube)
- hystero- = referring to the uterus tubes (also Eustacian /auditory tube)
--> hysterectomy = removal of the uterus