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Herpes Virus (Herpes Simplex 1 (dsDNA, enveloped with glycoprotein spikes,…
Herpes Virus
Herpes Simplex 1
dsDNA
enveloped with glycoprotein spikes
latent housing trigeminal nerve
endemic worldwide
oral > genital
oral-oral; oral-genital; fetal during delivery
mostly asymptomatic
whitlow, facialis, gingivostomatitis, encephalitis, kertaoconjunctivitis, retinitis, eczema herpeticum, integumentalis, neonatal herpes
acyclovir, famciclovir, velacyclovir
Cytomegalvirus
enveloped
typically infects multinucleated cells
latency in mononucleocytes
saliva, urine, secual, breast milks, organs, transfusions
fever, sore throat, fatigue, swollen glands, mononucleosis, hepatitis
Congenital Cytomegalovirus = small head, small body, seizures, hearing and vision loss, mental dysfunction, death
supportive treatment only
General Characteristics
circulating antibody helps but does not prevent
first eruptions are worst
establishes latent infection
recurrence via immunosuppression
persists in host indefinitely
no cure
Types
herpes simplex virus type 1
herpes simplex virus type 2
epstein barr virus
cytomegalovirus
varicella zoster virus
herpes virus 6
herpes virus 8
Epstein Barr Virus
maternal antibody for protection
enveloped
body fluids: saliva > blood > semen
remains dormant in throat and blood
Herpes Simplex 2
.
latent housing in sacral or lumbar ganglion
genital > oral
sexual transmission
asymptomatic --> mild (fever, aches, lymphnodalitis)
whitlow, encephalitis, retinitis, herpeticum, integumentalis