Please enable JavaScript.

Coggle requires JavaScript to display documents.

Adipose tissue (tissue organization (nerves (sympathetic nervous system,…

- - - - pre-adipocytes
        
        phagocytic activity toward micro-organisms
        
        function disappears when differentiated ointo adipocytes
      - fibroblasts
      - endothelial cells
      - immune cells
        
        macrophages
        
        remove dead cells
      - adipocytes
        
        production of endocrine proteins
        
        adipokines
        
        adiponectin
        
        leptin
        
        proinflammatory regulators
        
        IL-6
        
        monocyte chemoattractant protein 1=MPC-1
        
        tumor necrosis factor a=TNF-a
        
        lipid storage
        
        variable size
        
        :red_flag:in obesity, cell size heterogeneity :arrow_down:
  - - - TNF receptors present in proximal area, decreases in distal parts of AT
  - - - not known why
- - - - immune cells
        
        5%
      - other cells
        
        95%
  - - - other cells
        
        50%
      - immune cells
        
        50%
    - - morphology
        
        crown-like structures
      - endocrinology
        
        MPC-1 :arrow_up:
        
        resulting in increased peripheral monocyte infiltration to the site
        
        monocyte differentiation into macrophages
        
        adiponectin :arrow_down:
    - - hypertrophy
        
        cell size :arrow_up:
      - hyperplasia
        
        cell number:arrow_up:
    - - overgrowth of adipocytes
        
        hypoxia
        
        adipocyte necrosis
        
        upreg. inflammatory cytokines
        
        inflitration of macrophages
        
        adiponectin :arrow_down:
        
        macrophage differentiation to M1
- - - - stimulating angiogenesis
    - - triggers proliferation
    - - regulation of preadipocyte proliferation and differentiation
    - - :red_flag:elevated levels in obese individuals :red_flag:
      - decreases preadipocyte number
      - inhibiting differentiation of adipocytes
      - larger cells secreting more TNF-alfa
    - - :red_flag:elevated levels in obese individuals :red_flag:
    - - local mitogen
      - antagonizes adipose cell differentiation
    - - dexamethasone
  - - - increases fat cell proliferation
      - inhibits lipolysis